GALR1 - galanin receptor 1 Gene

Also Known as GALNR; GALNR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2587

About GALR1

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:77,249,848-77,277,900 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 1.2), brain (RPKM 0.7) and 7 other tissues.

Summary

The neuropeptide Galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

GALR1 Products (1)

mRNA Protein Name
NM_001480.4 NP_001471.2 galanin receptor type 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables galanin receptor activity IDA
IDA: Inferred from direct assay
24517231 GOA
enables peptide hormone binding IDA
IDA: Inferred from direct assay
24517231 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cortisol secretion IMP
IMP: Inferred from mutant phenotype
17982695 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24517231 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 303)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

galanin receptor type 1

  • GAL1-R

GALR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GALR1 P47211 P22466-PRO_0000010449 Homo sapiens P22466-PRO_0000010449
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 18q Deletion Syndrome

  • 18q- Syndrome

  • Monosomy 18q

  • Deletion Of Long Arm Of Chromosome 18

  • Chromosome 18q- Syndrome

  • Deletion 18q

  • 18q Deletion Syndrome

  • Distal 18q Deletion Syndrome

  • Chromosome 18 Long Arm Deletion Syndrome

  • Chromosome 18q Monosomy

  • Del Syndrome

  • Chromosome 18 Deletion Syndrome
Auditory Agnosia
Benign Essential Hypertension
Mood Disorder

  • Mood Disorders

  • Episodic Mood Disorder
Lynch Syndrome I

  • Lynch Syndrome 1

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1

  • HNPCC1

  • Fcc1

  • Lynch Syndrome Ii

  • Colon Cancer, Familial Nonpolyposis, Type 1

  • Coca1

  • Familial Nonpolyposis Colon Cancer Type 1

  • Hereditary Nonpolyposis Colorectal Cancer Type 1

  • Hereditary Non-Polyposis Colorectal Cancer 1

  • Hereditary Non-Polyposis Colorectal Cancer 3

  • Hnpcc3

  • Lynch Cancer Family Syndrome

  • Lynch Syndrome

  • Lynch Syndrome Type I

  • Lynch Syndrome Type Ii

  • Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1

  • Hereditary Nonpolyposis Colorectal Cancer

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 3

  • Hereditary Non-Polyposis Colon Cancer Type 2
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1127 Galanin (1-30), human Agonist 99.91% Unkown
HY-P1130 M871 Antagonist 99.98% Unkown
HY-123671 CYM2503 Modulator 96.01% Unkown
HY-P5064 Galanin-Like Peptide (porcine) Agonist / Unkown
HY-P5894 human GALP (3-32) Antagonist / Unkown
HY-RS05264 GALR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20934 Galr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27451 Galr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GALR1 VGNC VGNC:29239
Canis familiaris GALR1 VGNC VGNC:41100
Macaca mulatta GALR1 VGNC VGNC:104222
Mus musculus GALR1 MGD MGI:1096364
Rattus norvegicus GALR1 RGD RGD:2656
Felis catus GALR1 VGNC VGNC:62456
Others GALR1 NCBI