CID15997213
CID15997213 is a blood-brain barrier penetrating antiviral agent. CID15997213 targets the amino-terminal domain of the VEEV nonstructural protein 2 (nsP2). CID15997213 shows alphavirus-specific antiviral effect, inhibiting VEEV and Western equine encephalitis virus.
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- No. CAS: 900134-28-3
- Fòrmula: C21H22FN5O3
- Peso molecular:411.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero 76 | CC50 |
>50 μM
Compound: 1
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Cytotoxicity against african green monkey Vero 76 cells after 3 days by Celltiter-Glo reagent based assay
Cytotoxicity against african green monkey Vero 76 cells after 3 days by Celltiter-Glo reagent based assay
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[PMID: 25244572] |
| Vero 76 | EC50 |
0.3 μM
Compound: 1
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Antiviral activity against Venezuelan equine encephalitis virus V3526 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus V3526 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
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[PMID: 25244572] |
| Vero 76 | EC50 |
0.6 μM
Compound: 1
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Antiviral activity against Venezuelan equine encephalitis virus TrD infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TrD infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
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[PMID: 25244572] |
| Vero 76 | EC50 |
0.8 μM
Compound: 1
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Antiviral activity against Venezuelan equine encephalitis virus TC83 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TC83 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
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[PMID: 25244572] |
Chemical Information
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No. CAS 900134-28-3
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Peso molecular 411.43
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Fòrmula C21H22FN5O3
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SMILES
O=C1C2=C(N=C(CN3CCN(CC3)CC)N1C4=C(F)C=CC=C4)C=CC([N+]([O-])=O)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CID15997213 Related Classifications
HY-171261 Related Classifications
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