CMLD012073
CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
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- No. CAS: 2368900-32-5
- Fòrmula: C30H30N2O7
- Peso molecular:530.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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ATPγS tetralithium salt (Standard)Reference Standard -
HY-101785R
eIF4A3-IN-2 (Standard)Reference Standard
Actividad biológica
Descripciòn
IC50 & Target
eIF4A[1]
In Vitro
In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 2368900-32-5
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Peso molecular 530.57
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Fòrmula C30H30N2O7
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SMILES
CC1=N[C@@]2(O)[C@H](C(OC)=O)[C@@H](C3=CC=CC=C3)[C@]4(C5=CC=C(OC)C=C5)OC6=C(C(OC)=CC(OC)=C6)[C@@]42N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CMLD012073 Related Classifications
HY-129769 Related Classifications
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