ENSA - endosulfine alpha Gene

Also Known as ARPP-19e

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2029

About ENSA

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,621,246-150,629,612 (from NCBI)

This gene has 15 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 40.0), esophagus (RPKM 33.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of Insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates Insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

ENSA Products (8)

mRNA	Protein	Name
NM_004436.4	NP_004427.1	alpha-endosulfine isoform 3
NM_207042.2	NP_996925.1	alpha-endosulfine isoform 1
NM_207043.2	NP_996926.1	alpha-endosulfine isoform 2
NM_207044.2	NP_996927.1	alpha-endosulfine isoform 4
NM_207045.2	NP_996928.1	alpha-endosulfine isoform 5
NM_207046.2	NP_996929.1	alpha-endosulfine isoform 6
NM_207047.2	NP_996930.1	alpha-endosulfine isoform 7
NM_207168.2	NP_997051.1	alpha-endosulfine isoform 8

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Referencias	Source
enables potassium channel inhibitor activity	IDA IDA: Inferred from direct assay	9653196	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9653196	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
acts upstream of or within regulation of insulin secretion	IDA IDA: Inferred from direct assay	9653196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENSA Protein Structure

Endosulfine

0
100
121 a.a.

Protein Preferred Names	Protein Names
alpha-endosulfine

ENSA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	ENSA	O43768	ACD	Homo sapiens	Q96AP0	BiFC	21044950
Intra	ENSA	O43768	ACD	Homo sapiens	Q96AP0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENSA Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P74175	ENSA Protein, Human (His)	O43768-1 (M1-E121)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77544	ENSA Protein, Human (Biotinylated, His)	O43768-1 (M1-E121)	≥ 95%, as determined by reducing SDS-PAGE.

ENSA Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83025	ENSA Antibody (YA2770)	WB, FC	Human, Mouse, Rat
HY-P83025A	ENSA Antibody (YA2770)(PBS only)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Type 1 Diabetes Mellitus 11	Diabetes Mellitus, Insulin-Dependent, 11 Iddm11 Insulin-Dependent Diabetes Mellitus 11 T1D11 Insulin-Dependent Diabetes Mellitus-11
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-156715	MASTL-IN-1	Inhibitor	99.54%	Unkown
HY-182391	MKI-3		/	Unkown
HY-185310	MKI-2	Inhibitor	/	Unkown
HY-RS04394	ENSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19130	Ensa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25620	Ensa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENSA	RGD	RGD:62007
Felis catus	ENSA	VGNC	VGNC:61877
Mus musculus	ENSA	MGD	MGI:1891189
Canis familiaris	ENSA	VGNC	VGNC:40379
Macaca mulatta	ENSA	VGNC	VGNC:99904
Bos taurus	ENSA	VGNC	VGNC:50171
Others	ENSA	NCBI