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Referencia número: HY-184786

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Tyk2-IN-14

Tyk2-IN-14 is a Tyk2 inhibitor that regulates IFNα and IL-23 by inhibiting Tyk2-mediated signal transduction. Tyk2-IN-14 exhibits an IC₅₀ of 0.08 μM against the IL-23 Kit225 reporter gene and an IC₅₀ of 0.09 μM against the IFNα Kit225 reporter gene. IL-23 modulator-1 is applicable to the research of inflammatory diseases and autoimmune diseases.

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No. CAS: 1609392-06-4
Fòrmula: C₁₈H₁₈N₆O₃S
Peso molecular:398.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

Tyk2-IN-14 Chemical Structure

No. CAS: 1609392-06-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

Tyk2	IL-23 0.08 μM (IC₅₀)

Ver todos los productos específicos de isoformas JAK :

Ver todos los productos específicos de isoformas Interleukin Related :

In Vitro

Tyk2-IN-14 (CPD31) inhibits IL-23-induced reporter gene activity in Kit225 T cells with an IC₅₀ of 0.08 μM; it also inhibits IFNα-induced reporter gene activity in Kit225 T cells with an IC₅₀ of 0.09 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

No. CAS 1609392-06-4
Peso molecular 398.44
Fòrmula C₁₈H₁₈N₆O₃S
SMILES

O=C(NC)C1=NN=C(C=C1NC=2C=CC=CC2S(=O)(=O)C)NC3=NC=CC=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Moslin R M, et al. AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES. WO2014074661A1. WIPO. 2014.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocolo
Pureza y Documentación
Referencias

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Tyk2-IN-14

Ver todos los productos específicos de isoformas JAK

Ver todos los productos específicos de isoformas Interleukin Related