EV-A71-IN-2
EV-A71-IN-2 (compound 6c) is a anti-EV-A71 agent with the EC50 values of 0.29 μM and 1.66 μM aganist of EV-A71-MRC-5 cells and EV-A71-RD cells, respectively. EV-A71-IN-2 can be used for study of enterovirus infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C21H18N4OS
- Molecular Weight:374.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | CC50 |
41.26 μM
Compound: 6c
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Cytotoxicity against Chinese hamster CHO-K1 cells incubated for 24 hrs by neutral red dye uptake assay
Cytotoxicity against Chinese hamster CHO-K1 cells incubated for 24 hrs by neutral red dye uptake assay
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[PMID: 39088999] |
| MRC5 | CC50 |
>20 μM
Compound: 6c
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Cytotoxicity against human MRC5 cells
Cytotoxicity against human MRC5 cells
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[PMID: 39088999] |
| RD | CC50 |
>40 μM
Compound: 6c
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Cytotoxicity against human RD cells
Cytotoxicity against human RD cells
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[PMID: 39088999] |
Chemical Information
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Molecular Weight 374.46
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Formel C21H18N4OS
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SMILES
OCC1=CC=C(C2=CC=C(SCC3=CC=C(N4C=NC=N4)C=C3)N=C2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EV-A71-IN-2 Related Classifications
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