Fengabine
Fengabine is a GABAergic antidepressant agent. Fengabine can be used for the research of depression.
For research use only. We do not sell to patients.
- CAS No.: 80018-06-0
- Formula: C17H17Cl2NO
- Molecular Weight:322.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Fengabine (150 mg/kg; i.p) decreases the percentage of time spent. Fengabine (25~50 mg/kg; i.p.) reverses the deficit in learning the step-down avoidance task[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:50 mg/kg
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Administration:I.p.
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Result:Prevented completely the learned helplessness induced by the unavoidable shock.
Chemical Information
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CAS No. 80018-06-0
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Molecular Weight 322.23
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Formula C17H17Cl2NO
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SMILES
OC1=CC=C(C=C1/C(C2=CC=CC=C2Cl)=N\CCCC)Cl
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Synonyms
SL 79229
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90. [Content Brief]
[2]. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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