Ferroptosis-IN-8
Based on 1 Customer Validation
Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis.
For research use only. We do not sell to patients.
- Purity: 98.24%
- CAS No.: 3056016-82-8
- Formula: C15H15N3O3
- Molecular Weight:285.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Cancer Compound Library
HY-L025
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Antioxidant Compound Library
HY-L037
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Ferroptosis Compound Library
HY-L051
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Cell Death Library
HY-L162
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Fibrosis Compound Library
HY-L185
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
IC50: 40.49 nM (Ferroptosis)
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Cell Line
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Type | Value | Description | References |
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| HT-1080 | EC50 |
40.49 nM
Compound: B4
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Inhibition of RSL3-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK8 assay
Inhibition of RSL3-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK8 assay
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[PMID: 38822802] |
Ferroptosis-IN-8 (Compound B4) (200 nM) effectively rescues HKC, HK-2, Khos, SW480, and HTR-8/SVneo cells from ferroptosis induced by RSL3 or FIN56[1]. Ferroptosis-IN-8 (Compound B4) (200 nM) againstes ferroptosis predominantly relies on their intrinsic antioxidative capacity, rather than classical signaling pathways including lipid oxidation metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells treatment with RSL3 or FIN56
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Concentration:200 nM
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Incubation Time:24 h
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Result:Effectively rescued HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells from ferroptosis induced by RSL3 or FIN56.
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Cell Line:HT-1080 cell
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Concentration:200 nM
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Incubation Time:
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Result:Didn't significantly affect the protein levels of key factors related to lipid metabolism (ACSL4, ALOX15, and COX2), glutathione metabolism pathways (GPX4, SLC7A11), and iron metabolism (DMT1, TFRC, and FTH1)
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:acetaminophen-induced acute liver injury mice model[1].
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Dosage:10 mg/kg
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Administration:intraperitoneal injection (i.p.)
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Result:Attenuated the increased plasma ALT and AST levels induced by acetaminophen, effectively reduced the injury response induced by acetaminophen[1].
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Animal Model:kidney ischemia−reperfusion injury mice model[1].
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Dosage:10 mg/kg, twice, 1 h before ischemia onset.
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Administration:intraperitoneal injection (i.p.)
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Result:Reduced the levels of creatinine and BUN and alleviated the increase in KIM-1 levels in the I/R model[1].
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Animal Model:
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Administration:
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Animal Model:
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Chemical Information
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CAS No. 3056016-82-8
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Appearance Solid
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Molecular Weight 285.30
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Formula C15H15N3O3
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Color Yellow to orange
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SMILES
NC1=C(C=CC=C1O)C(N/N=C/C2=CC=C(C=C2)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (175.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5051 mL | 17.5254 mL | 35.0508 mL | 87.6271 mL |
| 5 mM | 0.7010 mL | 3.5051 mL | 7.0102 mL | 17.5254 mL | |
| 10 mM | 0.3505 mL | 1.7525 mL | 3.5051 mL | 8.7627 mL | |
| 15 mM | 0.2337 mL | 1.1684 mL | 2.3367 mL | 5.8418 mL | |
| 20 mM | 0.1753 mL | 0.8763 mL | 1.7525 mL | 4.3814 mL | |
| 25 mM | 0.1402 mL | 0.7010 mL | 1.4020 mL | 3.5051 mL | |
| 30 mM | 0.1168 mL | 0.5842 mL | 1.1684 mL | 2.9209 mL | |
| 40 mM | 0.0876 mL | 0.4381 mL | 0.8763 mL | 2.1907 mL | |
| 50 mM | 0.0701 mL | 0.3505 mL | 0.7010 mL | 1.7525 mL | |
| 60 mM | 0.0584 mL | 0.2921 mL | 0.5842 mL | 1.4605 mL | |
| 80 mM | 0.0438 mL | 0.2191 mL | 0.4381 mL | 1.0953 mL | |
| 100 mM | 0.0351 mL | 0.1753 mL | 0.3505 mL | 0.8763 mL |
Ferroptosis-IN-8 Related Classifications
HY-163654 Related Classifications
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