Ferroptosis inducer-10
Ferroptosis inducer-10 is a ferroptosis inducer. Ferroptosis inducer-10 can inhibit A549 cells growth with an IC50 of 0.76 μM. Ferroptosis inducer-10 can deplete GSH, elevate ROS and MDA, and downregulate GPX4 expression. Ferroptosis inducer-10 can induce cell G2/M phase and inhibit migration. Ferroptosis inducer-10 can be used for the research of cancer, such as non-small lung cancer.
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- Fòrmula: C19H14N2O2
- Peso molecular:302.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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GPX4 |
Ferroptosis inducer-10 (Compound I-21) shows antiproliferative activity in A549, HT-1080, MCF-7, Panc-02 and PC-3 cells with IC50 values of 0.76, 1.03, 4.86, 3.41 and 1.34 μM, respectively[1].
Ferroptosis inducer-10 shows no noticeable toxicity toward HUVEC cells (IC50 = 24.66 μM) [1].
Ferroptosis inducer-10 (0.5-4 μM) increases ROS and MDA levels and decreases GSH levels in A549 cells[1]
Ferroptosis inducer-10 (0.5-4 μM, 12 h) increases Fe2+ levels in A549 cells[1].
Ferroptosis inducer-10 (0.5-4 μM) induces cells crumpling and fragmentation in A549 cells[1].
Ferroptosis inducer-10 (0.5-2 μM, 12-24 h) downregulates GPX4 levels in A549 cells[1].
Ferroptosis inducer-10 (1-4 μM, 24 h) induces G2/M phase arrest in A549 cells[1].
Ferroptosis inducer-10 (0.5-2 μM, 7 days) reduces form colonies in A549 cells[1].
Ferroptosis inducer-10 (0.5-4 μM, 48 h) inhibits migration in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:0.5, 1 and 2 μM
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Incubation Time:12 and 24 h
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Result:Downregulated GPX4 levels.
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Cell Line:A549 cells
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Concentration:1, 2 and 4 μM
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Incubation Time:24 h
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Result:Increased the G2/M phase percentage.
Decreased S and G1 proportion.
Chemical Information
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Peso molecular 302.33
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Fòrmula C19H14N2O2
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SMILES
O=C1C(NC2=CC=CC3=C2C=CC=N3)CC(C4=CC=CC=C41)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ferroptosis inducer-10 Related Classifications
HY-175811 Related Classifications
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