Fludarabine-Cl
Based on 2 publication(s) in Google Scholar
Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases.
For research use only. We do not sell to patients.
- Purity : 99.71%
- CAS No.: 2734853-80-4
- Formula: C10H11ClFN5O3
- Molecular Weight:303.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Fludarabine-Cl
More
Biological Activity
Description
IC50 & Target
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ADAR1 0.87 μM (IC50) |
In Vitro
Fludarabine-Cl inhibits tumor cell proliferation, and has only a weak inhibitory effect on normal RWPE1 and HEK293 cells. The IC50 for MDA-MB-23, RPMI822, HL60 and K562 is 0.383, 0.149, 0.544 and 0.609 μM[1].
Fludarabine-Cl binds to ADAR1 protein with a KD of 7.24 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Fludarabine-Cl (10-20 mg/kg, intraperitoneal injection, twice a day, for 29 days) inhibits tumor proliferation in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[1]
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Dosage:104.9, 131.1, 163.8, 204.8, 256, 320, 400 mg/kg; twice a day; one day
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Administration:Intraperitoneal injection (i.p.)
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Result:Was somewhat toxic and could cause death in mice at higher doses, but no abnormality in organs.
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Animal Model:BALB/c mice induced by Du-145[1]
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Dosage:10, 20 mg/kg; twice a day; 29 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth and had no effect on mouse body weight.
Chemical Information
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CAS No. 2734853-80-4
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Appearance Solid
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Molecular Weight 303.68
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Formula C10H11ClFN5O3
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Color White to off-white
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SMILES
NC1=NC(F)=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CCl)O3
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Synonyms
ZYS-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
Targeting ADAR1 lactylation activates innate immune and overcomes chemoresistance in ovarian cancer. [Abstract]2026 May 25. PMID: 42185630 -
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fludarabine-Cl Related Classifications
HY-145443 Related Classifications
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