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SEC13 - SEC13 homolog, nuclear pore and COPII coat complex component Gene

Also Known as SEC13R; npp-20; SEC13L1; D3S1231E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6396

About SEC13

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,300,931-10,321,112 (from NCBI)

This gene has 19 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 31.7), small intestine (RPKM 28.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]

SEC13 Products (5)

mRNA	Protein	Name
NM_001136026.3	NP_001129498.1	protein SEC13 homolog isoform 3
NM_001136232.3	NP_001129704.1	protein SEC13 homolog isoform 2
NM_001278946.2	NP_001265875.1	protein SEC13 homolog isoform 5
NM_030673.4	NP_109598.2	protein SEC13 homolog isoform 4
NM_183352.3	NP_899195.1	protein SEC13 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18160040	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15146057	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in COPII-coated vesicle cargo loading	IDA IDA: Inferred from direct assay	17499046	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	35831510	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35831510	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	17499046	GOA
part of GATOR2 complex	IDA IDA: Inferred from direct assay	35831510	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	15146057	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	28199306	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	15146057	GOA
part of nuclear pore outer ring	IDA IDA: Inferred from direct assay	17360435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC13 Protein Structure

WD40

0
100
200
300
322 a.a.

Protein Preferred Names	Protein Names
protein SEC13 homolog	GATOR complex protein SEC13

SEC13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SEC13	P55735	SEC16B	Homo sapiens	Q96JE7-2	Validated Y2H	25416956
Intra	SEC13	P55735	SEC16B	Homo sapiens	Q96JE7-2	Y2H Prey Pooling	25416956
Intra	SEC13	P55735	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	33961781
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Y2H Array	27194810
Intra	SEC13	P55735	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	28514442
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Anti Tag CoIP	28514442
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Anti Tag CoIP	33961781
Intra	SEC13	P55735	SEH1L	Homo sapiens	Q96EE3	Anti Tag CoIP	35271311
Intra	SEC13	P55735	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	35271311
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Anti Tag CoIP	35271311
Intra	SEC13	P55735	SEH1L	Homo sapiens	Q96EE3	Anti Tag CoIP	33961781
Intra	SEC13	P55735	SEH1L	Homo sapiens	Q96EE3	Y2H Array	27194810
Cross	SEC13	P55735	NUP145	Saccharomyces cerevisiae	P49687	X-Ray Diffraction	18160040
Cross	SEC13	P55735	NUP145	Saccharomyces cerevisiae	P49687	GMS	18160040
Cross	SEC13	P55735	NUP145	Saccharomyces cerevisiae	P49687	Y2H Array	27194810
Intra	SEC13	P55735	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	35271311
Intra	SEC13	P55735	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	33961781
Intra	SEC13	P55735	TRAF5	Homo sapiens	O00463	Validated Y2H	25416956
Intra	SEC13	P55735	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	SEC13	P55735	SEC16B	Homo sapiens	Q96JE7	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Craniolenticulosutural Dysplasia	Boyadjiev-Jabs Syndrome CLSD Cranio-Lenticulo-Sutural Dysplasia Cranio-Lenticulo-Sutural Dysplasia, Clsd
Anemia, Congenital Dyserythropoietic, Type Ii	Congenital Dyserythropoietic Anemia Type Ii CDAN2 Cda Ii Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test Cda Type Ii Congenital Dyserythropoietic Anemia Type 2 Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test Sec23b-Cdg Congenital Dyserythropoietic Anemia, Type Ii Dyserythropoietic Anemia, Hempas Type Hempas Cda Type 2 Dyserythropoietic Anemia, Congenital, Type Ii Cda, Type Ii Congenital Dyserythropoietic Anaemia Type 2 Congenital Dyserythropoietic Anaemia Type Ii Anemia, Dyserythropoietic, Congenital Type 2 Hempas Anemia Dyserythropoietic Anemia, Congenital Type 2 Anemia, Congenital Dyserythropoietic, 2 Dyserythropoietic Anemia Hempas Type Anemia, Dyserythropoietic Congenital, Type Ii Anemia, Dyserythropoietic, Congenital, Type Ii
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12605	SEC13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21752	Sec13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28270	Sec13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEC13	VGNC	VGNC:77149
Felis catus	SEC13	VGNC	VGNC:64960
Bos taurus	SEC13	VGNC	VGNC:34403
Rattus norvegicus	SEC13	RGD	RGD:1359555
Canis familiaris	SEC13	VGNC	VGNC:45962
Mus musculus	SEC13	MGD	MGI:99832
Others	SEC13	NCBI