SEC16B - SEC16 homolog B, endoplasmic reticulum export factor Gene

Also Known as RGPR; LZTR2; SEC16S; PGPR-p117; RGPR-p117

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89866

About SEC16B

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:177,928,788-177,984,284 (from NCBI)

This gene has 8 transcripts (splice variants), 170 orthologues and 1 paralogue. Broad expression in small intestine (RPKM 16.8), duodenum (RPKM 16.0) and 22 other tissues.

Summary

SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

SEC16B Products (5)

mRNA Protein Name
NM_001356499.2 NP_001343428.1 protein transport protein Sec16B isoform 2
NM_001390833.1 NP_001377762.1 protein transport protein Sec16B isoform 1
NM_001390834.1 NP_001377763.1 protein transport protein Sec16B isoform 4
NM_001390835.1 NP_001377764.1 protein transport protein Sec16B isoform 4
NM_033127.4 NP_149118.2 protein transport protein Sec16B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum organization IDA
IDA: Inferred from direct assay
21768384 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
21478858 GOA
involved in peroxisome fission IMP
IMP: Inferred from mutant phenotype
21768384 GOA
involved in peroxisome organization IDA
IDA: Inferred from direct assay
21768384 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21768384 GOA
involved in positive regulation of protein exit from endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
21768384 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
21478858 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
21768384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC16B Protein Structure

Sec16

Sec16: Vesicle coat trafficking protein Sec16 mid-region (278 - 378)

Sec16_C

Sec16_C: Sec23-binding domain of Sec16 (446 - 679)

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  • 800
  • 1000
  • 1060 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec16B

  • leucine zipper transcription regulator 2

SEC16B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEC16B Q96JE7 SEC13 Homo sapiens P55735
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12610 SEC16B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SEC16B VGNC VGNC:82505
Bos taurus SEC16B VGNC VGNC:34407
Rattus norvegicus SEC16B RGD RGD:621658
Canis familiaris SEC16B VGNC VGNC:45966
Macaca mulatta SEC16B VGNC VGNC:100136
Mus musculus SEC16B MGD MGI:2148802
Others SEC16B NCBI