PAA5
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity.
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- Formule: C14H8Au5B2F8N2-
- Masse moléculaire:1348.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
PAA5 (0-4 μM; 24 h) induces ferroptosis and increase of the ferroptosis marker gene prostaglandin-endoperoxide synthase 2 (PTGS2). PAA5 decreases cell viability in EJ cells with IC50 values of 1.0 μM and 2.7 μM for EJ and HUVEC cells, respectively[1].
PAA5 (1.5 μM; 4 h; EJ and HUVEC cells) releases active Au(I) metabolites within cells and increases GSH and ROS level[1].
PAA5 (4 μM; 1, 3 and 6 h, EJ cells) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC, EJ cells
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Concentration:0, 0.5, 1, 1.5, 2, and 4 µM
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Incubation Time:24 hours
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Result:Decreased cell viability of EJ cells 57 and 55%, respectively, compare with HUVEC cells.
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Cell Line:EJ cells
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Concentration:4 µM
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Incubation Time:1, 3, and 6 hours
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Result:Increased the expression of pH2AX in a time dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-6 weeks, 18 g, female BALB/c nude mice[1]
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Dosage:1.5 µM, 100 µL
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Administration:Intravesical delivered into the bladder; 5 times every other day for 8 days
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Result:Exhibited a good antitumor effect with the small average tumor volume of 564 ± 180 mm3 after 22 days and no significant body weight loss.
Chemical Information
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Masse moléculaire 1348.66
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Formule C14H8Au5B2F8N2-
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SMILES
[F-][B+3]([F-])([F-])[F-].[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au@@]56[Au@]27[Au]358[Au]46)=[N]([Au]78)C9=C%10C=CC=C9)=C%10C=CC=C1.[2+]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAA5 Related Classifications
HY-149036 Related Classifications
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