Sarcophine
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum.
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- CAS No.: 55038-27-2
- Formule: C20H28O3
- Masse moléculaire:316.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
10.38 μg/mL
Compound: 6
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Cytotoxicity against human A549 cells after 6 days by MTT assay
Cytotoxicity against human A549 cells after 6 days by MTT assay
|
10.1021/np960174n |
| A549 | IC50 |
>40 μM
Compound: 5
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Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
|
[PMID: 21458279] |
| HCT-116 | IC50 |
>40 μM
Compound: 5
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Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
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[PMID: 21458279] |
| HL-60 | IC50 |
34.7 μM
Compound: 5
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Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
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[PMID: 21458279] |
| HT-29 | ED50 |
10.46 μg/mL
Compound: 6
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Cytotoxicity against human HT29 cells after 6 days by MTT assay
Cytotoxicity against human HT29 cells after 6 days by MTT assay
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10.1021/np960174n |
| KB | ED50 |
>50 μg/mL
Compound: 6
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Cytotoxicity against human KB cells after 3 days by MTT assay
Cytotoxicity against human KB cells after 3 days by MTT assay
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10.1021/np960174n |
| MCF7 | IC50 |
>40 μM
Compound: 5
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Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
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[PMID: 21458279] |
| P388 | ED50 |
2.42 μg/mL
Compound: 6
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Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
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10.1021/np960174n |
Sarcophine ((+)-Sarcophine) is an inhibitor of recombinant glycine receptors, with a Ki value of 2.1 μM[1].
Sarcophine (1-100 mM; 24 h) has cytotoxicity against HEK293 cells with an LD50 value of 29.3 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 55038-27-2
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Masse moléculaire 316.43
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Formule C20H28O3
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SMILES
O=C1C(C)=C2[C@](O1)([H])/C=C(C)/CC[C@H]3[C@](O3)(C)CC/C=C(C)/CC2
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Synonyms
(+)-Sarcophine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarcophine Related Classifications
HY-124550 Related Classifications
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