FTase-IN-1
FTase-IN-1 (compound 17a) is a potent and specific inhibitor of fanesyl transferase (FTase) with an IC50 of 0.35 μM. FTase-IN-1 displays cytotoxicity potential and antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2490538-41-3
- Formula: C23H16N2O2S
- Molecular Weight:384.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.35 μM (fanesyl transferase)[1]
FTase-IN-1 (compound 17a) (10 μM, 48 h) is an inhibitors of farnesyl transferase (FTase) and inhibits NCI-60 cells proliferation in vitro[1].
FTase-IN-1 (10 μM, 48 h) arrests the cell growth of multiple cancer cell lines with GI50 range from 1.8 to 6.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer)
-
Concentration:10 μM
-
Incubation Time:48 hours
-
Result:Inhibited cell growth and showed strong antitumor activity.
Chemical Information
-
CAS No. 2490538-41-3
-
Molecular Weight 384.45
-
Formula C23H16N2O2S
-
SMILES
CC(C1=CC(C(C2=CC=C3NC4=C(C=CC=C4)SC3=C2)=O)=C5C=CC=CN15)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTase-IN-1 Related Classifications
HY-149015 Related Classifications
Powered by Bioz