GABA-T ASO
GABA-T ASO is an antisense oligodeoxynucleotide targeting GABA-transaminase (GABA-T) mRNA, which blocks GABA-T synthesis and elevates GABA levels. GABA-T ASO is complementary to the translation initiation codon region. GABA-T ASO exerts a protective effect against psychostimulant-induced convulsions. GABA-T ASO prevents pentylenetetrazol-induced convulsions. GABA-T ASO can be used for research on convulsions.
For research use only. We do not sell to patients.
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vivo
GABA-T ASO (7.2 nM; i.c.v.; single administration; 15 hours before PTZ) prevents pentylenetetrazole-induced seizures in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Balb/cByJ (male, 21-32 g)[1]
-
Dosage:0.288 nM; 0.864 nM; 1.152 nM; 1.440 nM; 1.44 nM (15 h); 1.44 nM (8 h); 1.44 nM (36 h)
-
Administration:unilateral i.c.v.; single administration; challenge 15, 8, or 36 hours later
-
Result:Induced seizures in mice at 0.288 nM with 100%.
Experienced seizures at 0.864 nM with 83%.
Experienced seizures at 1.152 nM with one mouse.
-
Animal Model:Balb/cByJ (male, 21-32 g)[1]
-
Dosage:1.44 nM; 7.2 nM
-
Administration:unilateral i.c.v.; single administration; PTZ challenge 15 hours later
-
Result:The 1.44 nM dose of GABA-T ASO had no effect on seizures.
All mice given 7.2 nM GABA-T ASO were seizure free.
Chemical Information
-
Appearance Solid
-
Color White to off-white
-
SMILES
[GABA-T ASO]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2242 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GABA-T ASO Related Classifications
HY-188172 Related Classifications
Powered by Bioz
Keywords
- GABA-T ASO
- GABA Receptor
- Gamma-aminobutyric acid Receptor
- γ-Aminobutyric acid Receptor
- GABA
- GABA-Transaminase
- anticonvulsant
- antisense oligodeoxynucleotide
- intracerebroventricular
- mRNA
- pentylenetetrazol-induced seizures
- psychostimulant-induced seizures
- seizure threshold
- translation start codon
- Inhibitor
- inhibitor
- inhibit