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Art. -Nr.: HY-188172A

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GABA-T Scramble control ASO

GABA-T Scramble control ASO is a scrambled control antisense oligonucleotide with no complementarity to known genes. GABA-T Scramble control ASO can be used as a negative control for in vivo GABA-T (ABAT) knockdown to demonstrate the specificity of target reduction. GABA-T Scramble control ASO can be used in research related to metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Data Sheet (268 KB)

GABA-T Scramble control ASO Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vivo

Lipid Metabolism

The scramble control ASO (12.5 mg/kg; i.p.; twice weekly; 1-4 weeks) does not alter pancreatic or whole-brain GABA-T mRNA expression, glucoregulatory measures in lean mice, or leptin sensitivity in obese mice, confirming the specificity of the GABA-T-targeted ASO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 20-26 weeks, diet-induced obesity)^[1]
Dosage:

12.5 mg/kg
Administration:

i.p.; twice weekly; 1 or 4 weeks
Result:

Did not alter pancreatic or whole-brain GABA-T mRNA expression.
Did not affect body weight or glucoregulatory measures in lean mice.
Did not affect food intake or relative weight change following leptin injection in obese mice.

Related Protocols :

Chemical Information

Appearance Solid
Color White to off-white
SMILES

[GABA-T Scramble control ASO]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

Verweise

[1]. Geisler CE, et al. A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity. Cell reports. 2021 Jun 29;35(13):109301.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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