Galacto-PUGNAc
Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders.
For research use only. We do not sell to patients.
- CAS No.: 1145878-98-3
- Formula: C15H19N3O7
- Molecular Weight:353.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Galacto-PUGNAc inhibits purified G. gallus GH 27 α-N-acetylgalactosaminidase with a Ki of 140 mM, showing 2800-fold selectivity for human lysosomal β-hexosaminidases[1].
Galacto-PUGNAc (200 μM; 9 days) increases GM2 ganglioside levels by 30-40% in human SK-N-SH neuroblastoma cells[1].
Galacto-PUGNAc (50 μM; overnight) does not increase O-GlcNAc-modified protein levels in cultured human SK-N-SH neuroblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1145878-98-3
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Molecular Weight 353.33
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Formula C15H19N3O7
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SMILES
O[C@@H]([C@@H](CO)O/1)[C@H](O)[C@@H](NC(C)=O)C1=N\OC(NC2=CC=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galacto-PUGNAc Related Classifications
HY-108241A Related Classifications
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