2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. Galacto-PUGNAc

Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders.

For research use only. We do not sell to patients.

Galacto-PUGNAc

Galacto-PUGNAc Chemical Structure

CAS No. : 1145878-98-3

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Other Forms of Galacto-PUGNAc:

Galacto-PUGNAc Related Antibodies

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Description

Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders[1].

In Vitro

Galacto-PUGNAc inhibits purified G. gallus GH 27 α-N-acetylgalactosaminidase with a Ki of 140 mM, showing 2800-fold selectivity for human lysosomal β-hexosaminidases[1].
Galacto-PUGNAc (200 μM; 9 days) increases GM2 ganglioside levels by 30-40% in human SK-N-SH neuroblastoma cells[1].
Galacto-PUGNAc (50 μM; overnight) does not increase O-GlcNAc-modified protein levels in cultured human SK-N-SH neuroblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Galacto-PUGNAc Related Antibodies
Molecular Weight

353.33

Formula

C15H19N3O7
CAS No.
SMILES

O[C@@H]([C@@H](CO)O/1)[C@H](O)[C@@H](NC(C)=O)C1=N\OC(NC2=CC=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Galacto-PUGNAc Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galacto-PUGNAc1145878-98-3GlycosidaseO-GlcNAcasehuman SK-N-SH neuroblastoma cellsGH 27 α-N-acetylgalactosaminidaseSandhoff diseaseslysosomal β-hexosaminidasesneurodegenerative disordershuman HEXAGM2 gangliosidehuman HEXBTay-Sachs diseasesInhibitorinhibitorinhibit

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