country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-160254

Copy Link Print Information

1954U89

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 150057-49-1
Fòrmula: C₁₆H₂₁N₅
Peso molecular:283.37

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

1954U89 Chemical Structure

No. CAS: 150057-49-1

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
143B	IC₅₀	0.8 nM Compound: 5o	Cytotoxic Activity was evaluated against 143B (TK-) tumor cells Cytotoxic Activity was evaluated against 143B (TK-) tumor cells	[PMID: 8632413]
A549	IC₅₀	0.4 nM Compound: 5o	Cytotoxic activity evaluated against A549 tumor cells Cytotoxic activity evaluated against A549 tumor cells	[PMID: 8632413]
Daoy	IC₅₀	2.3 nM Compound: 5o	Cytotoxic activity was evaluated against Daoy tumor cells Cytotoxic activity was evaluated against Daoy tumor cells	[PMID: 8632413]
HCT-8	IC₅₀	0.74 nM Compound: 5o	Activity was evaluated against HCT-8 tumor cells Activity was evaluated against HCT-8 tumor cells	[PMID: 8632413]
NCI-H460	IC₅₀	0.5 nM Compound: 5o	Cytotoxic Activity was evaluated against H460 tumor cells Cytotoxic Activity was evaluated against H460 tumor cells	[PMID: 8632413]
P388	IC₅₀	0.12 nM Compound: 5o	Cytotoxic activity was evaluated against P388D1 tumor cells Cytotoxic activity was evaluated against P388D1 tumor cells	[PMID: 8632413]
U-373MG ATCC	IC₅₀	2.3 nM Compound: 5o	Cytotoxic activity was evaluated against U373MG tumor cells Cytotoxic activity was evaluated against U373MG tumor cells	[PMID: 8632413]
U-87MG ATCC	IC₅₀	2.1 nM Compound: 5o	Cytotoxic activity was evaluated against U87MG tumor cells Cytotoxic activity was evaluated against U87MG tumor cells	[PMID: 8632413]
Vero	IC₅₀	1 nM Compound: 5o	Cytotoxic Activity was evaluated against Vero tumor cells Cytotoxic Activity was evaluated against Vero tumor cells	[PMID: 8632413]

Chemical Information

No. CAS 150057-49-1
Peso molecular 283.37
Fòrmula C₁₆H₂₁N₅
SMILES

CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Studenberg SD, et al. The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42. [Content Brief]

[2]. Chen J C, et al. QSAR Studies on a Series of 7, 8‐Dialkyl‐1, 3‐diaminopyrrolo‐[3, 2‐f] quinazolines with Anticancer Activity[J]. Chinese Journal of Chemistry, 2006, 24(11): 1531-1537.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto