Glabridin
Based on 13 publication(s) in Google Scholar
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.91%
- No. CAS: 59870-68-7
- Fòrmula: C20H20O4
- Peso molecular:324.37
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Glabridin
More- Phytomedicine. 2025 Sep:145:157081. [Abstract]
- Food Chem. 2025 Dec 30:497:146992. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Mol Med. 2023 Dec 8;29(1):167. [Abstract]
- Free Radic Biol Med. 2025 Aug 1:235:317-334. [Abstract]
- Int Immunopharmacol. 2024 Jun 30:135:112262. [Abstract]
- Parasit Vectors. 2024 Dec 18;17(1):522. [Abstract]
- Biochem Biophys Res Commun. 2026 Jun 25:819:153804. [Abstract]
- Biochem Biophys Res Commun. 2026 May 28:815:153580. [Abstract]
- Cytotechnology. 2025 Oct;77(5):184. [Abstract]
- Int J Morphol. 2024.
- University of Wyoming. 2025.
- bioRxiv. 2025 Feb 19.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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RT-PCR
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ELISA
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Histological Imaging/Staining
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PPARγ 6.1 μM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SW480 | IC50 |
21.4 μM
Compound: 66
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Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay
Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay
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[PMID: 26841168] |
In Vitro
Glabridin binds to and activates PPARγ, with an EC50 of 6115 nM[1].
Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h[2].
Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines[2].
Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, 8, and 9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 59870-68-7
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Appearance Solid
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Peso molecular 324.37
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Fòrmula C20H20O4
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Color Off-white to light yellow
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SMILES
OC1=CC=C([C@H]2CC3=CC=C4C(C=CC(C)(C)O4)=C3OC2)C(O)=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (13)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Amoebicidal action of isoliquiritigenin and glabridin from Glycyrrhiza species: Mechanisms and effects against Acanthamoeba castellanii. [Abstract]2025 Sep:145:157081. PMID: 40701128 -
Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Mol Med
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production. [Abstract]2023 Dec 8;29(1):167. PMID: 38066431
Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167. [Abstract]
BMDMs were first treated with DMSO or Glabridin (Glab) (0. 5, 10, 20 μM) of various concentrations for 1 h, and then stimulated with HT-DNA or Poly(I:C) for 2 h. Whole cell lysate (WCL) was collected and immunoblotted with the indicated antibody.
Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167. [Abstract]
BMDMs were treated with DMSO or Glabridin (Glab) (0. 5, 10, 20 μM) of various concentrations for 1 h, and then stimulated with HT-DNA for 4 h. The expression of IFN-β, IL-6 and TNF-α mRNA level were detected by quantitative polymerase chain reaction (qPCR) assay.
Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167. [Abstract]
Glabridin (20, 40 mg/kg, i.p.) (Glab) inhibits the activation of STING and downstream signaling pathway in vivo. Determination of IFN-β, IL-6 and TNF-α concentrations in collected serum by ELISA kits.
Glabridin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Dec 8;29(1):167. [Abstract]
Representative images of various tissues stained with hematoxylin–eosin (H&E) staining. Glabridin (20, 40 mg/kg, i.p.) (Glab) Alleviates the Autoinfammatory Response in Trex1−/− Mice.
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Free Radic Biol Med
Glabridin protects against paraquat-induced acute lung injury by targeting ME1 to mitigate oxidative stress, mitochondrial dysfunction, and cGAS-STING activation. [Abstract]2025 Aug 1:235:317-334. PMID: 40316060 -
Int Immunopharmacol
The Glabridin from Huangqin Decoction Prevents the Development of Ulcerative Colitis into Colitis-Associated Colorectal Cancer by Modulating MMP1/MMP3 Activity. [Abstract]2024 Jun 30:135:112262. PMID: 38805906 -
Parasit Vectors
Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo. [Abstract]2024 Dec 18;17(1):522. PMID: 39695816
Glabridin purchased from MedChemExpress. Usage Cited in: Parasit Vectors. 2024 Dec 18;17(1):522. [Abstract]
Cytotoxicity of Glabridin on Vero cells. Glabridin demonstrated low cytotoxicity in Vero cells. Cells were exposed to increasing concentrations of Glabridin (0, 2.5, 5, 7.5, 10, and 20 µg/mL) for 24 h. Cell viability was measured using the Cell Counting Kit-8 (CCK-8) assay, with results expressed as a percentage relative to the untreated control group.
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Biochem Biophys Res Commun
Glabridin promotes melanosome degradation and alleviates melanosome-induced mitochondrial dysfunction in keratinocytes via autophagy. [Abstract]2026 Jun 25:819:153804. PMID: 42019358 -
Biochem Biophys Res Commun
Glabridin attenuates diabetic cardiomyopathy by activating AMPK to suppress ferroptosis and TGF-β-mediated myocardial fibrosis. [Abstract]2026 May 28:815:153580. PMID: 41905164 -
Cytotechnology
2025 Oct;77(5):184. PMID: 41080973 -
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Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (77.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Rebhun JF, et al. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). Fitoterapia. 2015 Oct;106:55-61. [Content Brief]
[2]. Chen CT, et al. Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway. Environ Toxicol. 2018 Jun;33(6):679-685. [Content Brief]
[3]. El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26(2):551-559. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0829 mL | 15.4145 mL | 30.8290 mL | 77.0725 mL |
| 5 mM | 0.6166 mL | 3.0829 mL | 6.1658 mL | 15.4145 mL | |
| 10 mM | 0.3083 mL | 1.5414 mL | 3.0829 mL | 7.7072 mL | |
| 15 mM | 0.2055 mL | 1.0276 mL | 2.0553 mL | 5.1382 mL | |
| 20 mM | 0.1541 mL | 0.7707 mL | 1.5414 mL | 3.8536 mL | |
| 25 mM | 0.1233 mL | 0.6166 mL | 1.2332 mL | 3.0829 mL | |
| 30 mM | 0.1028 mL | 0.5138 mL | 1.0276 mL | 2.5691 mL | |
| 40 mM | 0.0771 mL | 0.3854 mL | 0.7707 mL | 1.9268 mL | |
| 50 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5414 mL | |
| 60 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2845 mL |
Glabridin Related Classifications
HY-N0393 Related Classifications
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