PSI-697
Based on 9 publication(s) in Google Scholar
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.79%
- No. CAS: 851546-61-7
- Fòrmula: C21H18ClNO3
- Peso molecular:367.83
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PSI-697
More- Chem Eng J. 382 (2020) 122848.
- Oncogene. 2019 Mar;38(12):2005-2019. [Abstract]
- Int J Nanomedicine. 2021 Aug 24;16:5777-5795. [Abstract]
- Cancer Immunol Res. 2022 Jun 3;10(6):770-784. [Abstract]
- ACS Appl Mater Interfaces. 2025 Jun 11;17(23):33513-33527. [Abstract]
- Mar Drugs. 2025 May 30;23(6):236. [Abstract]
- ACS Infect Dis. 2024 Aug 9;10(8):2656-2667. [Abstract]
- Thromb Res. 2020 Jan;185:160-166. [Abstract]
- ChemRxiv. 2025 Jun 11.
Customer Validation & Images
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IHC
Actividad biológica
IC50: 125 μM (P-selectin)[1]
PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-5 weeks male Sprague-Dawley rat (50-100 g)[1]
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Dosage:0 mg/kg, 30 mg/kg, 50 mg/kg
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Administration:Oral administration
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Result:At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 851546-61-7
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Appearance Solid
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Peso molecular 367.83
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Fòrmula C21H18ClNO3
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Color Light yellow to yellow
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SMILES
O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O
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Synonyms
P-Selectin Inhibitor
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
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Journal Impact Factor
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Most Recent
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PSI-697 purchased from MedChemExpress. Usage Cited in: Chem Eng J. 382 (2020) 122848.
Localization of NPs in H22 bearing tumor tissues. Mice bearing H22 tumors are intravenously injected with PLTM-HMnO2@Cur NPs and PSI-697 pre-treated (20 μg mL-1, 1 h) PLTM-HMnO2@Cur NPs. 24 h later, the tumors were removed and sectioned under frozen conditions followed by staining with an antibody against CD44 (green).
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Oncogene
Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis. [Abstract]2019 Mar;38(12):2005-2019. PMID: 30467381 -
Int J Nanomedicine
Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models. [Abstract]2021 Aug 24;16:5777-5795. PMID: 34471352 -
Cancer Immunol Res
2022 Jun 3;10(6):770-784. PMID: 35413115 -
ACS Appl Mater Interfaces
Platelet Membrane-Coated Drug-Loaded Nanoparticles for Dual-Modal Imaging and Photodynamic Therapy in Triple-Negative Breast Cancer. [Abstract]2025 Jun 11;17(23):33513-33527. PMID: 40423093 -
Mar Drugs
Exploring the Inhibitory Effects of Fucosylated Chondroitin Sulfate (FCS) Oligosaccharide Isolated from Stichopus horrens and the Derivatives on P-Selectin. [Abstract]2025 May 30;23(6):236. PMID: 40559645 -
ACS Infect Dis
P-selectin Facilitates SARS-CoV-2 Spike 1 Subunit Attachment to Vesicular Endothelium and Platelets. [Abstract]2024 Aug 9;10(8):2656-2667. PMID: 38912949 -
Thromb Res
Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via P-selectin. [Abstract]2020 Jan;185:160-166. PMID: 31821908 -
Solvente y solubilidad
DMSO : ≥ 45.8 mg/mL (124.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther. [Content Brief]
[2]. Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97(3):400-7. [Content Brief]
[3]. Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44(3):625-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7186 mL | 13.5932 mL | 27.1865 mL | 67.9662 mL |
| 5 mM | 0.5437 mL | 2.7186 mL | 5.4373 mL | 13.5932 mL | |
| 10 mM | 0.2719 mL | 1.3593 mL | 2.7186 mL | 6.7966 mL | |
| 15 mM | 0.1812 mL | 0.9062 mL | 1.8124 mL | 4.5311 mL | |
| 20 mM | 0.1359 mL | 0.6797 mL | 1.3593 mL | 3.3983 mL | |
| 25 mM | 0.1087 mL | 0.5437 mL | 1.0875 mL | 2.7186 mL | |
| 30 mM | 0.0906 mL | 0.4531 mL | 0.9062 mL | 2.2655 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6797 mL | 1.6992 mL | |
| 50 mM | 0.0544 mL | 0.2719 mL | 0.5437 mL | 1.3593 mL | |
| 60 mM | 0.0453 mL | 0.2266 mL | 0.4531 mL | 1.1328 mL | |
| 80 mM | 0.0340 mL | 0.1699 mL | 0.3398 mL | 0.8496 mL | |
| 100 mM | 0.0272 mL | 0.1359 mL | 0.2719 mL | 0.6797 mL |
PSI-697 Related Classifications
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