Quercetagetin
Based on 8 publication(s) in Google Scholar
Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.94%
- No. CAS: 90-18-6
- Fòrmula: C15H10O8
- Peso molecular:318.24
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-13653
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HispidulinPim-1 Inhibitor -
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SMI-16aPim Kinase Inhibitor -
HY-101870B
Uzansertib phosphatePIM Inhibitor -
HY-N4149R
Quercetagetin (Standard)Pim Inhibitor -
HY-18086
TCS PIM-1 1Pim-1 Inhibitor -
HY-13287
SGI-1776 free basePim/FLT3 Inhibitor -
HY-16576A
SMI-4aPim-1 Inhibitor -
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CX-6258 hydrochloridePim Kinases Inhibitor -
HY-15604
AZD1208PIM Inhibitor
Publications Citing Use of MedChemExpress (MCE) Quercetagetin
More- Metabolism. 2026 Jul:180:156622. [Abstract]
- Phytomedicine. 2025 Sep 11:148:157256. [Abstract]
- J Enzyme Inhib Med Chem. 2021 Dec;36(1):497-503. [Abstract]
- Nanoscale. 2020 Aug 20;12(32):16738-16754. [Abstract]
- Pharm Res. 2026 Jan 15. [Abstract]
- Bionanoscience. 2026 Jan 16;16(2):141.
- Cerebrovasc Dis. 2026 Aug 27:1.
- bioRxiv. 2020 Apr.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Flow Cytometry
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WB
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IF
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In Vivo Efficacy Study
Actividad biológica
Descripciòn
IC50 & Target
[2]|
PIM1 0.34 μM (IC50) |
PIM2 3.45 μM (IC50) |
RSK2 2.82 μM (IC50) |
PKA 21.2 μM (IC50) |
In Vitro
Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC50s of 3.45, 21.2, and 2.82 μM, respectively[2].
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Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RWPE2 prostate cancer cells
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Concentration:0.1, 1, 10, and 100 μM
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Incubation Time:72 hours
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Result:Inhibited growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SKH-1 hairless mice model[3]
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Dosage:4 or 20 nmol
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Administration:Topical application; 28 weeks
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Result:Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.
Chemical Information
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No. CAS 90-18-6
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Appearance Solid
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Peso molecular 318.24
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Fòrmula C15H10O8
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Color Light yellow to yellow
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SMILES
O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=C(O)C(O)=C13
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Synonyms
6-Hydroxyquercetin
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Metabolism
2026 Jul:180:156622. PMID: 41997496 -
Phytomedicine
Quercetagetin alleviates ischemic stroke injury by preserving macrophage/microglia homeostasis via inhibiting ACP5. [Abstract]2025 Sep 11:148:157256. PMID: 40972264
Quercetagetin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 11:148:157256. [Abstract]
BV2 cells were pretreated with solvent alone or pretreated with different concentrations of Quercetagetin (QG) (0 μM, 12.5 μM, 25 μM, and 50 μM) for 3 h prior to being subjected to OGD/R. The viability of BV2 cells was tested by CCK8 analysis.
Quercetagetin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 11:148:157256. [Abstract]
Application of flow cytometry to characterize M1 polarization levels treated with Quercetagetin (QG) (50 μM).
Quercetagetin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 11:148:157256. [Abstract]
The examination of ACP5 protein expression levels treated with Quercetagetin (QG) (50 μM).
Quercetagetin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 11:148:157256. [Abstract]
Representative images of PI-positive cells treated with Quercetagetin (QG) (50 μM).
Quercetagetin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 11:148:157256. [Abstract]
Mice were orally administered Quercetagetin (QG) at 15 mg/kg/day (tMCAO+QG-l group) and 30 mg/kg/day (tMCAO+QG-H group), or saline (tMCAO group) for seven consecutive days, 2 h after the last administration the mice underwent tMCAO surgery or sham operation after oral administration of saline. Infarct volume statistics.
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J Enzyme Inhib Med Chem
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. [Abstract]2021 Dec;36(1):497-503. PMID: 33491508 -
Nanoscale
Targeted GSH-exhausting and hydroxyl radical self-producing manganese-silica nanomissiles for MRI guided ferroptotic cancer therapy. [Abstract]2020 Aug 20;12(32):16738-16754. PMID: 32578659 -
Pharm Res
Novel Cocrystal of Quercetagetin: In vitro and in vivo Insights into Biopharmaceutical Performance. [Abstract]2026 Jan 15. PMID: 41540297 -
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Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (392.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Yang X, et al. Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric. 2011 Aug 15;91(10):1925-7. [Content Brief]
[2]. Holder S, et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. 2007 Jan;6(1):163-72. [Content Brief]
[3]. Baek S, et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1423 mL | 15.7114 mL | 31.4228 mL | 78.5571 mL |
| 5 mM | 0.6285 mL | 3.1423 mL | 6.2846 mL | 15.7114 mL | |
| 10 mM | 0.3142 mL | 1.5711 mL | 3.1423 mL | 7.8557 mL | |
| 15 mM | 0.2095 mL | 1.0474 mL | 2.0949 mL | 5.2371 mL | |
| 20 mM | 0.1571 mL | 0.7856 mL | 1.5711 mL | 3.9279 mL | |
| 25 mM | 0.1257 mL | 0.6285 mL | 1.2569 mL | 3.1423 mL | |
| 30 mM | 0.1047 mL | 0.5237 mL | 1.0474 mL | 2.6186 mL | |
| 40 mM | 0.0786 mL | 0.3928 mL | 0.7856 mL | 1.9639 mL | |
| 50 mM | 0.0628 mL | 0.3142 mL | 0.6285 mL | 1.5711 mL | |
| 60 mM | 0.0524 mL | 0.2619 mL | 0.5237 mL | 1.3093 mL | |
| 80 mM | 0.0393 mL | 0.1964 mL | 0.3928 mL | 0.9820 mL | |
| 100 mM | 0.0314 mL | 0.1571 mL | 0.3142 mL | 0.7856 mL |
Quercetagetin Related Classifications
HY-N4149 Related Classifications
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