Petadeferitrin
Based on 1 Customer Validation
Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity. Petadeferitrin can be used in research related to β-thalassemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.71%
- No. CAS: 911714-45-9
- Fòrmula: C16H21NO6S
- Peso molecular:355.41
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Petadeferitrin is a derivative of Desferrithiocin but has higher iron clearance efficiency compared to Desferrithiocin with an ICE (Iron Clearance Efficiency) value of 26.7[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 911714-45-9
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Appearance Solid
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Peso molecular 355.41
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Fòrmula C16H21NO6S
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Color Light yellow to khaki
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SMILES
O=C([C@]1(C)N=C(C2=CC=C(OCCOCCOC)C=C2O)SC1)O
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Synonyms
SP-420
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : ≥ 38 mg/mL (106.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bergeron RJ, et al. Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles. J Med Chem. 2012 Aug 23;55(16):7090-103. [Content Brief]
[3]. Taher A T, et al. Safety and pharmacokinetics of the oral iron chelator SP‐420 in β‐thalassemia[J]. American Journal of Hematology, 2017, 92(12): 1356-1361. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8137 mL | 14.0683 mL | 28.1365 mL | 70.3413 mL |
| 5 mM | 0.5627 mL | 2.8137 mL | 5.6273 mL | 14.0683 mL | |
| 10 mM | 0.2814 mL | 1.4068 mL | 2.8137 mL | 7.0341 mL | |
| 15 mM | 0.1876 mL | 0.9379 mL | 1.8758 mL | 4.6894 mL | |
| 20 mM | 0.1407 mL | 0.7034 mL | 1.4068 mL | 3.5171 mL | |
| 25 mM | 0.1125 mL | 0.5627 mL | 1.1255 mL | 2.8137 mL | |
| 30 mM | 0.0938 mL | 0.4689 mL | 0.9379 mL | 2.3447 mL | |
| 40 mM | 0.0703 mL | 0.3517 mL | 0.7034 mL | 1.7585 mL | |
| 50 mM | 0.0563 mL | 0.2814 mL | 0.5627 mL | 1.4068 mL | |
| 60 mM | 0.0469 mL | 0.2345 mL | 0.4689 mL | 1.1724 mL | |
| 80 mM | 0.0352 mL | 0.1759 mL | 0.3517 mL | 0.8793 mL | |
| 100 mM | 0.0281 mL | 0.1407 mL | 0.2814 mL | 0.7034 mL |
Petadeferitrin Related Classifications
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