Salbutamol
Based on 8 publication(s) in Google Scholar
Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.96%
- No. CAS: 18559-94-9
- Fòrmula: C13H21NO3
- Peso molecular:239.31
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Salbutamol
More- Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
- Chin Med J (Engl). 2026 Apr 23. [Abstract]
- J Hazard Mater Lett. 2025 Nov.
- Cell Rep. 2019 Dec 3;29(10):2929-2935.e4. [Abstract]
- Anal Chem. 2025 Jul 15;97(27):14220-14229. [Abstract]
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Respir Res. 2022 Dec 28;23(1):380. [Abstract]
- Mol Biol Rep. 2026 Feb 26;53(1):434. [Abstract]
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
Ver todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
β adrenergic receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.98 μM
Compound: (rac)-4
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Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
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[PMID: 19245211] |
In Vitro
Salbutamol (16 μM; 24 h) significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC803, SGC7901
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Concentration:16 μM
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Incubation Time:24 h
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Result:Increased β2-AR and ERK levels.
Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
In Vivo
Salbutamol (6 mg/kg; oral administration; 4 weeks) has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin induced diabetic rats[2]
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Dosage:6 mg/kg
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Administration:Oral administration (p.o.); 4 weeks
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Result:Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 18559-94-9
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Appearance Solid
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Peso molecular 239.31
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Fòrmula C13H21NO3
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Color White to off-white
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SMILES
OC(CNC(C)(C)C)C1=CC=C(O)C(CO)=C1
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Synonyms
Albuterol; AH-3365
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Nov;11(41):e2402393. PMID: 39229959
Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.
Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.
Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.
Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.
Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.
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Chin Med J (Engl)
Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment. [Abstract]2026 Apr 23. PMID: 42036893 -
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Cell Rep
2019 Dec 3;29(10):2929-2935.e4. PMID: 31801060 -
Anal Chem
2025 Jul 15;97(27):14220-14229. PMID: 40601392 -
Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
Respir Res
Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. [Abstract]2022 Dec 28;23(1):380. PMID: 36575527 -
Mol Biol Rep
Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]2026 Feb 26;53(1):434. PMID: 41746444
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (417.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Lu Y, et al. Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through β2-AR/ERK/EMT pathway. J Cancer. 2022 Jan 1;13(2):401-412. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1787 mL | 20.8934 mL | 41.7868 mL | 104.4670 mL |
| 5 mM | 0.8357 mL | 4.1787 mL | 8.3574 mL | 20.8934 mL | |
| 10 mM | 0.4179 mL | 2.0893 mL | 4.1787 mL | 10.4467 mL | |
| 15 mM | 0.2786 mL | 1.3929 mL | 2.7858 mL | 6.9645 mL | |
| 20 mM | 0.2089 mL | 1.0447 mL | 2.0893 mL | 5.2234 mL | |
| 25 mM | 0.1671 mL | 0.8357 mL | 1.6715 mL | 4.1787 mL | |
| 30 mM | 0.1393 mL | 0.6964 mL | 1.3929 mL | 3.4822 mL | |
| 40 mM | 0.1045 mL | 0.5223 mL | 1.0447 mL | 2.6117 mL | |
| 50 mM | 0.0836 mL | 0.4179 mL | 0.8357 mL | 2.0893 mL | |
| 60 mM | 0.0696 mL | 0.3482 mL | 0.6964 mL | 1.7411 mL | |
| 80 mM | 0.0522 mL | 0.2612 mL | 0.5223 mL | 1.3058 mL | |
| 100 mM | 0.0418 mL | 0.2089 mL | 0.4179 mL | 1.0447 mL |
Salbutamol Related Classifications
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