Antitubercular agent-28
Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC50 value of 1.5 µM, an MIC value of 4.5 µM, an IC90 value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity.
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- No. CAS: 2460651-10-7
- Fòrmula: C17H14N4O2
- Peso molecular:306.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Antitubercular agent-28 (compound 2) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC50s of 2.9, 125, 130, 1.3, 3.8 µM, MICs of 3.3, 170, 190, 1.8, 8.4 µM, IC90s of 3.1, 140, 180, 1.5, 4.8 µM for FQ-R1, INH-R1, INH-R2, RIF-R1,RIF-R2 respectively[1].
Antitubercular agent-28 (0-200 µM) shows antibacterial activity with an MIC value of 170 µM, IC50 value of 2.96 µM, and IC90 value of 19 µM in low oxygen condition, and an MIC value of 1.77 µM, IC50 value of 1.02 µM, and IC90 value of 1.34 µM in normal oxygen condition[1].
Antitubercular agent-28 (0-200 µM) shows intracellular activity with an IC50 value of 2.15 µM, and IC90 value of 2.85 µM, and low cytotoxicity with an IC50 value of >100 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2460651-10-7
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Peso molecular 306.32
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Fòrmula C17H14N4O2
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SMILES
O=C(NN1C(C2CC2)=NC3=C(C=CC=C3)C1=O)C4=CC=NC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitubercular agent-28 Related Classifications
HY-147884 Related Classifications
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