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Referencia número: HY-135743

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Apovincamine

Name: Apovincamine
Brand: MedChemExpress
SKU: HY-135743
Price: 298.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: cis-Apovincamine; (+)-Apovincamine)

Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity.

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No. CAS: 4880-92-6
Fòrmula: C₂₁H₂₄N₂O₂
Peso molecular:336.43

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Apovincamine Chemical Structure

No. CAS: 4880-92-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	49.8 μM Compound: apovincamine	Antimelanogenic activity in mouse B16 cells assessed as decrease in intracellular melanin level after 4 days Antimelanogenic activity in mouse B16 cells assessed as decrease in intracellular melanin level after 4 days	[PMID: 20576577]
INS1(832/13)	EC₅₀	5.03 μM Compound: Vin-A01	Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay	[PMID: 31918073]

In Vitro

Apovincamine (cis-Apovincamine; 6.3, 12.5, 25, 50, 100 μM) dose-dependently inhibits cells viability with an IC₅₀ of 49.8 μM and shows anti-melanogenesis in B16 mouse melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 4880-92-6
Peso molecular 336.43
Fòrmula C₂₁H₂₄N₂O₂
SMILES

[H][C@]12[C@]3(CC)C=C(C(OC)=O)N(C4=CC=CC=C45)C1=C5CCN2CCC3
Synonyms

cis-Apovincamine; (+)-Apovincamine
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Koichiro Koyama, et al. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophore. Bioorg Med Chem. 2010 Jun 15;18(12):4415-21. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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