Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora

  • Bioorg Med Chem. 2010 Jun 15;18(12):4415-21. doi: 10.1016/j.bmc.2010.04.086.
Koichiro Koyama  1 ,  Yusuke Hirasawa ,  Takahiro Hosoya ,  Teh Chin Hoe ,  Kit-Lam Chan ,  Hiroshi Morita
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.
PMID: 20576577 DOI: 10.1016/j.bmc.2010.04.086
Abstract

Eight new Indole Alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in B16 mouse melanoma cells.

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