AZD2836
AZD2836 (A-831) is a 4-aminopyrazolone compound with anti-HCV activity. AZD2836 inhibits the activity of the host cell kinase PI4KIIIα, causing metabolic disorder of the cell membrane component PI4P that is necessary for viral replication. In the HCV subgenomic replicon cell model, the EC50 values of AZD2836 for genotype 1b (Con1 strain) and genotype 1a (Lemon strain) are 270 nM and 550 nM, respectively.
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- No. CAS: 944278-62-0
- Fòrmula: C24H20N6O2
- Peso molecular:424.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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PI4KIIIα |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 944278-62-0
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Peso molecular 424.45
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Fòrmula C24H20N6O2
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SMILES
COC(C=CC(C(C=C12)=CC=C1N=CN=C2NC(C=C3)=CC=C3N4N=CN=C4)=C5)=C5OC
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Synonyms
A-831
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZD2836 Related Classifications
HY-123536 Related Classifications
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