BMS-193884
BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 176960-47-7
- Fòrmula: C20H17N3O4S
- Peso molecular:395.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-P0202
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AtrasentanEndothelin Receptor Antagonist -
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ClazosentanETA Receptor Antagonist -
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BQ-788 sodium saltETB Receptor Antagonist -
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Atrasentan hydrochlorideETA Receptor Antagonist -
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TezosentanET Receptor Antagonist -
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IRL-1620ETB Agonist -
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Bosentan hydrateET1 Receptor Antagonist
Actividad biológica
Descripciòn
IC50 & Target
[1]|
ETA 1.4 nM (Ki) |
ETB 18700 nM (Ki) |
Chemical Information
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No. CAS 176960-47-7
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Peso molecular 395.43
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Fòrmula C20H17N3O4S
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SMILES
O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-193884 Related Classifications
HY-19263 Related Classifications
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