BMS-846372
BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM). BMS-846372 may be used in migraine research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1190363-03-1
- Fòrmula: C28H27F2N5O3
- Peso molecular:519.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-N-MC | IC50 |
0.22 nM
Compound: 5, BMS-846372
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Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
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[PMID: 24900474] |
Chemical Information
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No. CAS 1190363-03-1
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Peso molecular 519.54
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Fòrmula C28H27F2N5O3
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SMILES
O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)O[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CC6=CC=CN=C64
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Leahy DK, et al. Efficient and scalable enantioselective synthesis of a CGRP antagonist. Org Lett. 2012 Sep 21;14(18):4938-41. [Content Brief]
[2]. Luo G, et al. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. ACS Med Chem Lett. 2012 Feb 27;3(4):337-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-846372 Related Classifications
HY-12367 Related Classifications
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