BMS-986188
Based on 1 Customer Validation
BMS-986188 is a selective positive allosteric modulator of δ-opioid receptor with an EC50 of 0.05 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.06%
- No. CAS: 1776115-10-6
- Fòrmula: C30H31BrO4
- Peso molecular:535.47
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Opioid Receptor
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
>10 μM
Compound: 10, BMS-986188
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Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after 90 mins by beta-arrestin recruitment assay
Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after 90 mins by beta-arrestin recruitment assay
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[PMID: 25901762] |
| CHO | EC50 |
0.05 μM
Compound: 10, BMS-986188
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Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response after 90 mins by beta-arrestin recruitment assay
Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response after 90 mins by beta-arrestin recruitment assay
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[PMID: 25901762] |
Chemical Information
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No. CAS 1776115-10-6
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Appearance Solid
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Peso molecular 535.47
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Fòrmula C30H31BrO4
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Color Off-white to light yellow
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SMILES
O=C1C2=C(CC(C)(C1)C)OC(CC(C)(CC3=O)C)=C3C2C4=CC=C(C=C4)OCC5=CC=CC=C5Br
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 62.5 mg/mL (116.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8675 mL | 9.3376 mL | 18.6752 mL | 46.6880 mL |
| 5 mM | 0.3735 mL | 1.8675 mL | 3.7350 mL | 9.3376 mL | |
| 10 mM | 0.1868 mL | 0.9338 mL | 1.8675 mL | 4.6688 mL | |
| 15 mM | 0.1245 mL | 0.6225 mL | 1.2450 mL | 3.1125 mL | |
| 20 mM | 0.0934 mL | 0.4669 mL | 0.9338 mL | 2.3344 mL | |
| 25 mM | 0.0747 mL | 0.3735 mL | 0.7470 mL | 1.8675 mL | |
| 30 mM | 0.0623 mL | 0.3113 mL | 0.6225 mL | 1.5563 mL | |
| 40 mM | 0.0467 mL | 0.2334 mL | 0.4669 mL | 1.1672 mL | |
| 50 mM | 0.0374 mL | 0.1868 mL | 0.3735 mL | 0.9338 mL | |
| 60 mM | 0.0311 mL | 0.1556 mL | 0.3113 mL | 0.7781 mL | |
| 80 mM | 0.0233 mL | 0.1167 mL | 0.2334 mL | 0.5836 mL | |
| 100 mM | 0.0187 mL | 0.0934 mL | 0.1868 mL | 0.4669 mL |
BMS-986188 Related Classifications
HY-120024 Related Classifications
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