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Referencia número: HY-119899

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BO-0742

BO-0742, a derivative of AHMA and N-mustard, is a potent anti-cancer agent. BO-0742 significantly suppresses the growth of xenografts of human breast and ovarian cancers in mice.

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No. CAS: 774234-08-1
Fòrmula: C₂₆H₂₇Cl₂N₃O₂
Peso molecular:484.42

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BO-0742 Chemical Structure

No. CAS: 774234-08-1

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

BO-0742, a derivative of AHMA and N-mustard, is a potent anti-cancer agent. BO-0742 significantly suppresses the growth of xenografts of human breast and ovarian cancers in mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.0056 μM Compound: 8	Antiproliferative activity against human A549 cell line Antiproliferative activity against human A549 cell line	[PMID: 16759114]
A549	IC₅₀	0.0056 μM Compound: 9	Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.007 μM Compound: 6, BO-0742	Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 19124250]
CCRF-CEM	IC₅₀	0.007 μM Compound: 8	Antiproliferative activity against human CCRF-CEM cell line Antiproliferative activity against human CCRF-CEM cell line	[PMID: 16759114]
CCRF-CEM	IC₅₀	0.007 μM Compound: 9	Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.0075 μM Compound: 6, BO-0742	Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 19124250]
CCRF-CEM	IC₅₀	0.0075 μM Compound: 8	Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line	[PMID: 16759114]
CCRF-CEM	IC₅₀	0.0075 μM Compound: 9	Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.03 μM Compound: 9	Concentration required for growth inhibition of taxol resistant human lymphoblastic leukemic cell line (CCRF-CEM/taxol) was determined Concentration required for growth inhibition of taxol resistant human lymphoblastic leukemic cell line (CCRF-CEM/taxol) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.034 μM Compound: 6, BO-0742	Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 19124250]
CCRF-CEM	IC₅₀	0.034 μM Compound: 8	Antiproliferative activity against human taxol resistant CCRF-CEM cell line Antiproliferative activity against human taxol resistant CCRF-CEM cell line	[PMID: 16759114]
CCRF-CEM	IC₅₀	12.8 nM Compound: 6, BO-0742	Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 18450456]
CCRF-CEM	IC₅₀	3.2 nM Compound: 6, BO-0742	Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 18450456]
CCRF-CEM	IC₅₀	3.33 nM Compound: 6, BO-0742	Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 18450456]
HCT-116	IC₅₀	0.0055 μM Compound: 6, BO-0742	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 19124250]
HCT-116	IC₅₀	0.0055 μM Compound: 8	Antiproliferative activity against human HCT116 cell line Antiproliferative activity against human HCT116 cell line	[PMID: 16759114]
HCT-116	IC₅₀	0.0055 μM Compound: 9	Concentration required for growth inhibition of human HCT116 colon tumor cell line (CCRF-CEM) was determined Concentration required for growth inhibition of human HCT116 colon tumor cell line (CCRF-CEM) was determined	[PMID: 15324894]
HCT-116	IC₅₀	6.5 nM Compound: 6, BO-0742	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 18450456]
MX1	IC₅₀	0.0035 μM Compound: 6, BO-0742	Cytotoxicity against human MX1 cells after 72 hrs by SRB assay Cytotoxicity against human MX1 cells after 72 hrs by SRB assay	[PMID: 19124250]
MX1	IC₅₀	0.0035 μM Compound: 8	Antiproliferative activity against human MX1 cell line Antiproliferative activity against human MX1 cell line	[PMID: 16759114]
MX1	IC₅₀	3.5 nM Compound: 6, BO-0742	Cytotoxicity against human MX1 cells after 72 hrs by SRB assay Cytotoxicity against human MX1 cells after 72 hrs by SRB assay	[PMID: 18450456]

Chemical Information

No. CAS 774234-08-1
Peso molecular 484.42
Fòrmula C₂₆H₂₇Cl₂N₃O₂
SMILES

OCC1=CC(OCCN(CCCl)CCCl)=CC(NC2=C3C=CC=CC3=NC4=CC=CC=C42)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chien-Hsin Lee, et al. BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors. Cancer Lett. 2009 Apr 18;276(2):204-11. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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