CHF-2993
CHF-2993 is an orally active anticonvulsant. CHF-2993 antagonizes Bicuculline (HY-N0219)- and Picrotoxin (HY-101391)-induced tonic convulsions in mice, shows no activity against Pentylenetetrazole-induced clonic convulsions in mice, and partially reduces Veratridine (HY-N6691)-induced aspartate efflux in rat cortical synaptosomes. CHF-2993 can be used in the research of epilepsy.
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- No. CAS: 202914-21-4
- Fòrmula: C12H16N2O2
- Peso molecular:220.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vivo
CHF-2993 (multiple administrations; oral administration) antagonizes bicuculline-induced tonic seizures in male CD-1 mice, with an oral ED50 of 65 mg/kg[1].
CHF-2993 (multiple administrations; oral administration) exerts a protective effect against picrotoxin-induced tonic convulsions in male CD-1 mice, with an oral ED50 of 14 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 202914-21-4
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Peso molecular 220.27
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Fòrmula C12H16N2O2
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SMILES
N([C@H](C(N)=O)CO)C1CC=2C(C1)=CC=CC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHF-2993 Related Classifications
HY-118018 Related Classifications
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