CU-CPD107
Based on 1 Customer Validation
CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.07%
- No. CAS: 2573912-32-8
- Fòrmula: C16H21IN2O2
- Peso molecular:400.25
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7 μM[1].
CU-CPD107 (0-100 μM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA[1].
CU-CPD107 (100 μM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2573912-32-8
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Appearance Solid
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Peso molecular 400.25
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Fòrmula C16H21IN2O2
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Color White to off-white
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SMILES
IC1=C(C2=CC=CC=C2)N(CC(C)(C)O)C(COCC)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (312.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4984 mL | 12.4922 mL | 24.9844 mL | 62.4610 mL |
| 5 mM | 0.4997 mL | 2.4984 mL | 4.9969 mL | 12.4922 mL | |
| 10 mM | 0.2498 mL | 1.2492 mL | 2.4984 mL | 6.2461 mL | |
| 15 mM | 0.1666 mL | 0.8328 mL | 1.6656 mL | 4.1641 mL | |
| 20 mM | 0.1249 mL | 0.6246 mL | 1.2492 mL | 3.1230 mL | |
| 25 mM | 0.0999 mL | 0.4997 mL | 0.9994 mL | 2.4984 mL | |
| 30 mM | 0.0833 mL | 0.4164 mL | 0.8328 mL | 2.0820 mL | |
| 40 mM | 0.0625 mL | 0.3123 mL | 0.6246 mL | 1.5615 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4997 mL | 1.2492 mL | |
| 60 mM | 0.0416 mL | 0.2082 mL | 0.4164 mL | 1.0410 mL | |
| 80 mM | 0.0312 mL | 0.1562 mL | 0.3123 mL | 0.7808 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6246 mL |
CU-CPD107 Related Classifications
HY-147310 Related Classifications
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