DPC 684
DPC 684 is a potent and selective HIV-1 protease inhibitor (IC90 = 5.7-40 nM, Ki = 0.021 nM). DPC 684 competitively inhibits HIV-1 protease and blocks viral polyprotein cleavage. DPC 684 has low protein binding and broad-spectrum inhibition against a variety of wild-type and mutant HIV-1 proteases. DPC 684 has low protein binding and broad-spectrum inhibition (IC90 = 1.9-6.3 nM). DPC 684 has research significance for HIV.
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- No. CAS: 284661-73-0
- Fòrmula: C35H48FN5O5S
- Peso molecular:669.85
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
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HIV-1 0.021 nM (Ki) |
DPC 684 (Compound DPC 684) exhibits broad-spectrum anti-HIV-1 activity, requiring an average concentration of 14.5 nM for 90% inhibition of viral replication across cell models (MT-2: HIV-1 RF, IIIB strains; PBMC: HIV-1 IIIB, NL4-3 strains)[1].
DPC 684 exhibits antiviral activity against laboratory and clinical isolates (IC90: 5.7 nM, 7.8 nM for RF; 12 nM for HXB2; 20 nM for NL4-3; 8.8 nM, 40 nM for IIIB; 11 nM for Thai 9466 and Patient E; 32 nM for HIV-2)[1].
DPC 684 maintains high efficacy against common clinical drug-resistant mutations in MT-2 cells, with an IC90 of 8.8 nM for the D30N mutation (no loss of potency) and 26 nM for multiple mutations (2-fold reduction in potency)[1].
DPC 684 does not significantly inhibit 17 human proteases (including renin and pepsin) at a concentration of 13 μM, demonstrating its high selectivity for HIV protease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | CL | Cmax |
|---|---|---|---|---|
| Dog | 1 mg/kg | i.v. | 0.94 L/h/kg | / |
| Dog | 10 mg/kg | p.o. | / | 0.3 μM |
| Dog | 100 mg/kg | p.o. | / | 15 μM |
| Dog | 30 mg/kg | p.o. | / | 4.3 μM |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 284661-73-0
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Peso molecular 669.85
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Fòrmula C35H48FN5O5S
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SMILES
O=S(N(CC(C)C)C[C@@H](O)[C@@H](NC([C@H](C(C)(C)C)NC(CNCC1=CC(F)=CC=C1)=O)=O)CC2=CC=CC=C2)(C3=CC=C(C=C3)N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DPC 684 Related Classifications
HY-171835 Related Classifications
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