Edoxaban M4
Based on 1 Customer Validation
Edoxaban M4 (D21-2393) is an orally active and selective Factor Xa inhibitor with a human Factor Xa IC50 of 1.8 nM. Edoxaban M4 exhibits anticoagulant activity via Factor Xa inhibition. Edoxaban M4 can be used for the research of non-valvular atrial fibrillation, venous thromboembolisms, pulmonary embolism.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.83%
- No. CAS: 834919-19-6
- Fòrmula: C22H25ClN6O5S
- Peso molecular:520.99
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Heterocyclic Compound Library
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Metabolic Enzyme Compound Library
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Highly Selective Inhibitors Library
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Actividad biológica
Chemical Information
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No. CAS 834919-19-6
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Appearance Solid
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Peso molecular 520.99
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Fòrmula C22H25ClN6O5S
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Color White to off-white
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SMILES
O=C(O)[C@@H]1C[C@H]([C@H](CC1)NC(C(NC2=NC=C(C=C2)Cl)=O)=O)NC(C3=NC4=C(CN(CC4)C)S3)=O
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Synonyms
D21-2393
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 25 mg/mL (47.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Siriez R, et al. Importance of measuring pharmacologically active metabolites of edoxaban: development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method. J Thromb Thrombolysis. 2020;49(3):395-403. [Content Brief]
[2]. Kathrin I Foerster, et al. Simultaneous quantification of direct oral anticoagulants currently used in anticoagulation therapy. J Pharm Biomed Anal. 2018 Jan 30;148:238-244. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9194 mL | 9.5971 mL | 19.1942 mL | 47.9856 mL |
| 5 mM | 0.3839 mL | 1.9194 mL | 3.8388 mL | 9.5971 mL | |
| 10 mM | 0.1919 mL | 0.9597 mL | 1.9194 mL | 4.7986 mL | |
| 15 mM | 0.1280 mL | 0.6398 mL | 1.2796 mL | 3.1990 mL | |
| 20 mM | 0.0960 mL | 0.4799 mL | 0.9597 mL | 2.3993 mL | |
| 25 mM | 0.0768 mL | 0.3839 mL | 0.7678 mL | 1.9194 mL | |
| 30 mM | 0.0640 mL | 0.3199 mL | 0.6398 mL | 1.5995 mL | |
| 40 mM | 0.0480 mL | 0.2399 mL | 0.4799 mL | 1.1996 mL |
Edoxaban M4 Related Classifications
HY-119124 Related Classifications
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