FAP-IN-8
FAP-IN-8 (Compound 12i) is a potent inhibitor of PREP and FAP, with pIC50 values of 8.99 and 10.08 for FAP and PREP, and IC50 values of 1 and 0.08 nM, respectively. FAP-IN-8 may be used in cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3075119-33-1
- Fòrmula: C32H36N8O6
- Peso molecular:628.68
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
Chemical Information
-
No. CAS 3075119-33-1
-
Peso molecular 628.68
-
Fòrmula C32H36N8O6
-
SMILES
O=C(C1=CC=NC2=C1C=C(C=C2)OCCCN3CCOCC3)NCC(N4[C@H](CCC4)C(C(NCN5C6=C(N=N5)C=CC=C6)=O)=O)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
[1]. Brzeminski P, et al. Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential. J Med Chem. 2025 Oct 23;68(20):21739-21765. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAP-IN-8 Related Classifications
HY-178981 Related Classifications
Powered by Bioz