KLK3 - kallikrein related peptidase 3 Gene

Also Known as APS; PSA; hK3; KLK2A1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 354

About KLK3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,854,915-50,860,764 (from NCBI)

This gene has 15 transcripts (splice variants), 146 orthologues and 12 paralogues. Restricted expression toward prostate (RPKM 4286.7).

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. The gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]

KLK3 Products (3)

mRNA	Protein	Name
NM_001030047.1	NP_001025218.1	prostate-specific antigen isoform 3 preproprotein
NM_001030048.1	NP_001025219.1	prostate-specific antigen isoform 4 preproprotein
NM_001648.2	NP_001639.1	prostate-specific antigen isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18714013	GOA
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IMP IMP: Inferred from mutant phenotype	8665956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1725227	GOA
enables serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	15563730	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in positive regulation of antibacterial peptide production	IDA IDA: Inferred from direct assay	18714013	GOA
involved in proteolysis	IMP IMP: Inferred from mutant phenotype	15563730	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8665956	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	8665956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK3 Protein Structure

Trypsin

0
100
200
261 a.a.

Protein Preferred Names	Protein Names
prostate-specific antigen	P-30 antigen

Recombinant KLK3 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P70266	Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His)	P07288 (A18-P261)	≥ 95%, as determined by reducing SDS-PAGE.

KLK3 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81792	Prostate Specific Antigen Antibody (YA1537)	WB, IHC-P	Human
HY-P83986	Prostate Specific Antigen Antibody (YA3683)	IHC-P, FC, ELISA	Human
HY-P83986A	Prostate Specific Antigen Antibody (YA3683)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85338	Prostate Specific Antigen Antibody (YA5030)	IHC-P; IHC-F; IF-Tissue; ELISA	Human

Related Diseases

Diseases	Alias
Prostatitis
Urethral Stricture	Ankylurethria Urethral Stenosis Urethral Contracture Urethral Obstruction Meatal Stenosis Nos Constriction Of Urethra Contraction Of Urethra Stricture Of Urinary Meatus Urethral Obliteration Urethral Narrowing Pinpoint Meatus Pinhole Meatus Nos Urethral Occlusion
Nodular Prostate
Urethral Syndrome	Urethral Disease Urethral Diseases Urethra Disease Abnormality Of The Urethra Urethral Disorders
Prostatic Adenoma	Prostatic Hyperplasia Adenoma - Prostate Adenoma Of Prostate Benign Adenoma Of Prostate Prostate Adenoma Benign Prostatic Hyperplasia
Clear Cell Adenocarcinoma	Mesonephroma Water-Clear Cell Adenocarcinoma Adenocarcinoma, Clear Cell Malignant Mesonephroma Mesonephroid Clear Cell Carcinoma Mesonephroma, Malignant Water-Clear Cell Carcinoma Wolffian Duct Neoplasm Adenocarcinoma Clear Cell Mesonephric Tumor
Gynecomastia
Withdrawal Disorder	Withdrawal Syndrome Substance Withdrawal Syndrome
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Prostatic Hyperplasia, Benign	Benign Prostatic Hyperplasia BPH Prostatic Hyperplasia
Male Reproductive Organ Benign Neoplasm
Breast Cyst	Cyst Of The Breast Breast Cysts
Prostate Disease	Prostatic Diseases Prostate Diseases
Proctitis	Ulcerative Proctitis Chronic Ulcerative Proctitis Idiopathic Proctitis Nonspecific Ulcerative Proctitis Ulcerative Colitis Confined To Rectum Ip - [Idiopathic Proctitis] Chronic Ulcerative Proctitis Nos
Lymphocele	Lymph Cyst Lymphocele Adverse Event
Lower Urinary Tract Calculus	Calculus Of Lower Urinary Tract
Bladder Calculus	Urinary Bladder Calculi Urinary Bladder Stone Bladder Calculi Bladder Stone Urinary Bladder Calculus Vesical Calculi Vesical Calculus Vesicolithiasis Cystolithiasis Cystic Calculi Cystic Calculus
Prostate Sarcoma	Sarcoma Of The Prostate
Seminal Vesicle Cystadenoma
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Prostate Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Prostate Adenoid Cystic Carcinoma Of The Prostate
Prostatic Hypertrophy	Benign Prostatic Hypertrophy Prostatic Hyperplasia
Prostate Calculus	Calculus Of Prostate Prostatic Lithiasis Stone Of Prostate Prostatic Stone Prostate Calculi Prostatolithiasis
Prostate Leiomyoma	Prostatic Leiomyoma
Bladder Neck Obstruction	Obstruction Of Bladder Neck Or Vesicourethral Orifice Urinary Bladder Neck Obstruction Bladder Outlet Obstruction Vesicourethral Orifice Obstruction Bno - [Bladder Neck Obstruction] Bladder Obstruction Nos Acquired Bladder Neck Obstruction Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice Bladder Neck Strangulation Bladder Neck Stricture Bladder Outflow Obstruction Contracture Of Bladder Neck Or Sphincter Contracture Of Bladder Neck Obstructed Vesicourethral Orifice Strangulation Of Vesicourethral Orifice Stricture Of Vesicourethral Orifice Urinary Prostatic Valve Obstruction Vesical Obstruction
Prostate Stromal Sarcoma	Stromal Sarcoma Of The Prostate
Urethral Calculus	Calculus In Urethra Urethral Stone Urethrolithiasis Urethra Calculi Impaction Urethra Calculus Impaction Urethra Stone Calculous Urethritis Urethral Calculi Impaction Urethral Calculus Impaction
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Bladder Adenocarcinoma	Adenocarcinoma Of Bladder Adenocarcinoma Of The Urinary Bladder Bladder Adenocarcinoma, Not Otherwise Specified Adenocarcinoma Bladder
Prostatic Acinar Adenocarcinoma	Acinar Prostate Adenocarcinoma
Small Intestinal Sarcoma	Sarcoma Of The Small Intestine
Prostatic Cyst	Cyst Of Prostate
Seminal Vesicle Tumor	Tumor Of Seminal Vesicle Seminal Vesicle Neoplasm Seminal Vesicle Tumour Tumour Of Seminal Vesicle
Hypogonadism, Male	Male Hypogonadism Hypogonadism Male Testicular Hypogonadism
Pineal Dysgerminoma
Prostate Embryonal Rhabdomyosarcoma	Embryonal Rhabdomyosarcoma Of The Prostate
Endodermal Sinus Tumor	Yolk Sac Tumor Endodermal Sinus Tumour Hepatoid Yolk Sac Tumour Infantile Embryonal Carcinoma Yolk Sac Neoplasm Yolk Sac Tumour
Breast Disease	Breast Diseases
Glossopharyngeal Nerve Paralysis
Lymph Node Carcinoma	Lymph Node Cancer Lymph Node Neoplasm Neoplasm Of Lymph Node
Seminal Vesicle Adenocarcinoma
Hypogonadism
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Urinary System Disease	Abnormality Of The Urinary System Non-Neoplastic Urinary Tract Disease Urinary Tract Disease Urinary Tract Diseases Urinary Tract Anomaly Urologic Diseases Non-Neoplastic Urinary System Disorder Congenital Malformation Of The Urinary System
Epididymis Disease
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Prostate Lymphoma	Lymphoma Of Prostate
Male Reproductive Organ Cancer	Genital Neoplasms, Male Male Genital Cancer Male Genital Neoplasm Male Reproductive System Neoplasm Malignant Neoplasm Of Male Genital Organ Malignant Neoplasm Of Male Genital Organ Or Tract Malignant Neoplasm Of Male Genital Organs Malignant Tumor Of Male Genital Organ Malignant Tumor Of Male Reproductive System Neoplasm Of Male Genital Organ Tumor Of Male Reproductive System
Adenosquamous Prostate Carcinoma	Adenosquamous Carcinoma Of Prostate Adenosquamous Carcinoma Of The Prostate
Radiation Cystitis	Irradiation Cystitis
Prostatic Urethral Cancer
Nephrogenic Adenoma Of The Urethra	Nephrogenic Adenoma Of Urethra
Prostate Leiomyosarcoma	Leiomyosarcoma Of The Prostate
Female Breast Cancer	Female Breast Carcinoma Carcinoma Of Female Breast Mammary Carcinoma Of Female Breast Malignant Neoplasm Of Female Breast
Male Reproductive System Disease	Genital Diseases, Male Disorder Of Male Reproductive System
Prostate Small Cell Carcinoma	Small Cell Carcinoma Of Prostate Prostate Oat Cell Carcinoma
Female Urethral Cancer	Female Urethral Malignant Neoplasm
Epididymo-Orchitis
Cystadenoma	Cystoma Craniopharyngioma
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Sarcomatosis Of The Meninges	Meningeal Sarcomatosis Sarcomatosis Of Meninges
Pyuria	Pus Cells In Urine
Bladder Diverticulum	Diverticulum Of Bladder Diverticulum - Bladder Bladder Diverticula Vesical Diverticulum Bladder Sacculation
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Urethra Cancer	Cancer Of Urethra Malignant Tumour Of Urethra Malignant Urethral Neoplasm Urethral Ca
Rectal Disease	Rectal Diseases Rectal Disorders
Castration-Resistant Prostate Carcinoma	Prostatic Neoplasms, Castration-Resistant
Nephrogenic Adenoma	Nephrogenic Metaplasia
Urethral Diverticulum	Urethral Sacculation
Urinary Tract Infection	Urinary Tract Infections Uti Urinary Tract Infection Nos Uti - [Urinary Tract Infection] Uti Nos - [Urinary Tract Infection Nos] Urosepsis Nos E Coli Uti E Coli Urinary Tract Infection Escherichia Coli Uti
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Penile Urethral Cancer
Cystitis Cystica
Tuberculous Epididymitis	Tuberculosis Of Epididymis
Hemorrhoid	Hemorrhoids Hemorrhoidal Disease Rectal Diseases Piles Unspecified Haemorrhoids Without Complication
Urogenital Tuberculosis	Tuberculosis, Urogenital Genitourinary Tuberculosis
Male Urethral Cancer	Male Urethral Malignant Neoplasm
Laryngeal Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Larynx
Urethritis	Nonspecific Urethritis Non-Gonococcal Urethritis Nongonococcal Urethritis
Ureterolithiasis	Calculus Of Ureter Ureteric Stone Ureteral Calculi Ureteric Calculus Stone In The Ureter Ureter Calculi Ureteral Calculus Or Stone Ureterolith Ureterolithiasis Nos
Prostate Rhabdomyosarcoma	Rhabdomyosarcoma Of The Prostate
Urethral Benign Neoplasm	Urethral Neoplasms Neoplasm Of Urethra Neoplasm. Urethra Urethral Neoplasm Urethral Carcinoma Malignant Neoplasm Of Urethra
Cervical Adenoid Basal Carcinoma
Combined Oxidative Phosphorylation Deficiency 17	COXPD17 Combined Oxidative Phosphorylation Defect Type 17 Combined Oxidative Phosphorylation Deficiency, Type 17
Penile Disease	Penile Diseases
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Female Stress Incontinence	Female Urinary Stress Incontinence Stress Incontinence - Female
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Mixed Epithelial Stromal Tumour
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate
Inguinal Hernia	Hernia Inguinal Hernia, Inguinal Inguinal Hernias Bubonocele Indirect Inguinal Hernia Direct Inguinal Hernia Oblique Inguinal Hernia Scrotal Hernia Ih - [Inguinal Hernia]
Reproductive System Disease	Abnormality Of The Genital System Genital System Disease Reproductive System Disorder
Pelvic Varices	Varix Of Pelvis Pelvic Varicose Vein
Ureter Squamous Cell Carcinoma	Ureteral Epidermoid Carcinoma
Wolffian Duct Adenoma	Benign Mesonephroma Mesonephric Adenoma Mesonephroma, Benign Fatwo Female Adnexal Tumor Of Probable Wolffian Origin Wat Wolffian Adenoma Wolffian Adnexal Tumor Wolffian Tumor
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Bladder Tuberculosis	Tuberculous Cystitis Tuberculosis Of Bladder
Anus Disease	Anal Fissure Ulcer Of Anus Anus Diseases Anal Disease Anal Fissure And Fistula Anal Ulcer Fissure In Ano Nontraumatic Tear Of Anus Solitary Anal Ulcer Abnormality Of The Anus Anal Disorders Ulcer Of Anus And Rectum Solitary Ulcer Of Anus Stercoral Ulcer Of Anus
Epididymis Adenocarcinoma	Adenocarcinoma Of The Epididymis
Epididymis Cancer	Malignant Tumor Of Epididymis Malignant Epididymal Tumor Malignant Neoplasm Of Epididymis Neoplasm Of Epididymis
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Intrahepatic Bile Duct Adenoma	Adenoma Of Intrahepatic Bile Duct Adenoma Of The Intrahepatic Bile Duct
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-135794	11-Ketodihydrotestosterone	Agonist	99.87%	Unkown
HY-144127	AR antagonist 3	Antagonist	99.96%	Unkown
HY-168201	MJP6412		95.90%	Unkown
HY-RS07381	KLK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183667	JNJ-pan-AR	Inhibitor	/	Unkown
HY-181970	XY25026	Inhibitor	/	Unkown
HY-181971	XY25028	Inhibitor	/	Unkown
HY-184896	XYD113	Inhibitor	/	Unkown
HY-RS07388	KLKB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17665	Klkb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24126	Klkb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Others	KLK3	NCBI