JAK2-IN-18
JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. JAK2-IN-18 can inhibit JAK-STAT signaling and shows an IC50 of <100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 can inhibit the proliferation of abnormally proliferating myeloid cells and can be used for the research of myeloproliferative disorders, such as essential thrombocythemia.
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- No. CAS: 3108318-77-7
- Fòrmula: C37H36N8O4
- Peso molecular:656.73
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
JAK2 |
STAT5 |
Chemical Information
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No. CAS 3108318-77-7
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Peso molecular 656.73
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Fòrmula C37H36N8O4
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SMILES
COC(C(NC1=CC(NC(C2CC2)=O)=NN3C1=NC=C3)=CC=C4)=C4C5=CC(C6(CC6)C7)=C(C=C5)C(N7CC8=CC=CC(C(N(C)C)=O)=N8)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-18 Related Classifications
HY-179687 Related Classifications
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