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Referencia número: HY-138947

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KB-R7943

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC₅₀ value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models.

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No. CAS: 182004-64-4
Fòrmula: C₁₆H₁₇N₃O₃S
Peso molecular:331.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

KB-R7943 Chemical Structure

No. CAS: 182004-64-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC₅₀ value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models^[1].

Chemical Information

No. CAS 182004-64-4
Peso molecular 331.39
Fòrmula C₁₆H₁₇N₃O₃S
SMILES

NC(SCCC1=CC=C(OCC2=CC=C([N+]([O-])=O)C=C2)C=C1)=N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Aging Cell

Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription. [Abstract]

2022 May;21(5):e13593. PMID: 35353937
Br J Pharmacol

Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: likely role of Nav 1.6 inhibition in microglia. [Abstract]

2021 Sep;178(17):3553-3569. PMID: 33886140
J Am Heart Assoc

Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling. [Abstract]

2022 Aug 2;11(15):e025328. PMID: 35904193
Am J Physiol Cell Physiol

PFOS-induced Sertoli cell injury through c-Jun N-terminal kinase (JNK) - a study by RNA-Seq. [Abstract]

2024 Aug 1;327(2):C291-C309. PMID: 38826136

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Takahiro Kuramochi, et al. Discovery of N-(3-{4-[(3-fluorobenzyl)oxy]phenoxy}propyl)-2-pyridin-4-ylacetamide as a potent and selective reverse NCX inhibitor. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1043-7. [Content Brief]

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KB-R7943

4 Cited Publications

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KB-R7943

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Publications Citing Use of MedChemExpress (MCE) KB-R7943

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Publications (4)

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KB-R7943

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) KB-R7943

Actividad biológica

Chemical Information

Publications (4)

Pureza y Documentación

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KB-R7943 Related Classifications

HY-138947 Related Classifications