KP-19
KP-19 is a Propranolol (HY-B0573B) analogue. KP-19 can be used for the research of cardiovascular disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 145730-95-6
- Fòrmula: C16H30N2O2
- Peso molecular:282.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Chemical Information
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No. CAS 145730-95-6
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Peso molecular 282.42
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Fòrmula C16H30N2O2
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SMILES
CC1([C@@H](C/2)[C@H]1C[C@H](C)C2=N\OC[C@@H](O)CNC(C)C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)