KSK120
KSK120 is a potent inhibitor of drug-resistant infections with specific activity against Chlamydia trachomatis (C. trachomatis). KSK120 inhibits the developmental cycle of C. trachomatis, thereby reducing the infectivity of progeny bacteria. KSK120 targets the glucose-6-phosphate (G-6P) metabolic pathway of C. trachomatis, showing its potential application in antimicrobial inhibition. The mechanism of KSK120 may involve inhibition of the transcriptional machinery, which provides new ideas for the development of specific drugs against C. trachomatis infection.
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- No. CAS: 1638100-63-6
- Fòrmula: C28H22N2O2S
- Peso molecular:450.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
1.25 μM
Compound: 1; KSK 120
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Antimicrobial activity against Chlamydia trachomatis serovar LGV-L2 infected in human HeLa cells measured 44 to 48 hrs post infection by DAPI staining-based assay
Antimicrobial activity against Chlamydia trachomatis serovar LGV-L2 infected in human HeLa cells measured 44 to 48 hrs post infection by DAPI staining-based assay
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[PMID: 26849778] |
| HeLa | EC50 |
254 nM
Compound: 1; KSK 120
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Antimicrobial activity against Chlamydia trachomatis serovar LGV-L2 infected in human HeLa cells assessed as decrease in relative inclusion forming units measured 44 to 48 hrs post infection by DAPI staining-based assay
Antimicrobial activity against Chlamydia trachomatis serovar LGV-L2 infected in human HeLa cells assessed as decrease in relative inclusion forming units measured 44 to 48 hrs post infection by DAPI staining-based assay
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[PMID: 26849778] |
Chemical Information
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No. CAS 1638100-63-6
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Peso molecular 450.55
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Fòrmula C28H22N2O2S
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SMILES
O=C(C=C1CC2=CC=CC3=C2C=CC=C3)N4C(C(NC5=CC=CC=C5)=O)=CSC4=C1C6CC6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KSK120 Related Classifications
HY-117746 Related Classifications
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