KY1070
KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Human
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hBMP6 0.00014 μM (Kd) |
KY1070 (starting at a final concentration of 600 nM) binds recombinant human BMP6, neutralizes BMP6 from multiple species, lacks cross-reactivity to other BMPs, and inhibits BMPR heterodimerization (Kd = 140 pM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KY1070 (0.1-3 mg/kg) increases EPO sensitivity in male C57BL/6N mice with CKD[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bmp6 wild-type mice; Bmp6-deficient mice[1]
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Dosage:3 mg/kg
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Administration:single injection
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Result:Significantly decreased hepatic Hamp mRNA and increased plasma iron levels in Bmp6-wt mice; showed no effect on hepatic Hamp mRNA or plasma iron levels in Bmp6^-/- mice
P22004
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Petzer V, et al. A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease. Blood. 2020 Aug 27;136(9):1080-1090. [Content Brief]
[2]. Mansour GK, et al. Therapeutic targeting of the hepcidin-ferroportin axis and erythropoietic modulators: a narrative review. Front Med (Lausanne). 2025;12:1726337. Published 2025 Dec 9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KY1070 Related Classifications
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