L505-yne
L505-yne is an active site-directed γ-secretase inhibitor. L505-yne blocks photoaffinity labeling of PS1-NTF, PS1-CTF, and SPP by clickable GSI photoprobes, binds the γ-secretase complex and inhibits Aβ42 production. L458-BPyne can be used for the research of Alzheimer’s disease.
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- No. CAS: 1374647-07-0
- Fòrmula: C52H64N4O7
- Peso molecular:857.11
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
L505-yne (Compound 5) potently inhibits γ-secretase-mediated Aβ42 production in cell-free HeLa membranes (IC50 = 0.3 nM) and in CHO-APP cells (IC50 = 36 nM)[1].
L505-yne (20 nM; 1 h) prefers for PS1-CTF with minimal PS1-NTF labeling, but also revealed significant labeling of SPP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1374647-07-0
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Peso molecular 857.11
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Fòrmula C52H64N4O7
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SMILES
[C@@H](CC1=CC=CC=C1)(C[C@H]([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)O)C(N[C@H](C(N[C@@H](CC3=CC=C(C(=O)C4=CC=CC=C4)C=C3)C(NCCCCC#C)=O)=O)CC(C)C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L505-yne Related Classifications
HY-123761 Related Classifications
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