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Referencia número: HY-189090

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LEX-K02

LEX-K02 is a broad-spectrum and potent thiazole amide antifungal agent with an EC₅₀ of 0.140 μM. LEX-K02 inhibits fungal growth by disrupting the fungal cell membrane to cause leakage of intracellular substances and targeting the map00510 pathway to interfere with N-glycan biosynthesis. LEX-K02 can be used in studies related to Gaeumannomyces graminis infection.

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No. CAS: 3106140-37-5
Fòrmula: C₂₈H₂₂F₄N₂O₃S
Peso molecular:542.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEX-K02 Chemical Structure

No. CAS: 3106140-37-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

In Vitro

LEX-K02 (0.05-100 μM; 24 h-7 days) potently inhibits mycelial growth of Gaeumannomyces graminis with an EC₅₀ of 0.140 μM. It disrupts cell membrane integrity, increases cell membrane permeability, causes leakage of cytoplasmic contents, alters gene expression and metabolite levels in Gaeumannomyces graminis, and significantly impairs the N-glycan biosynthesis pathway^[1].
LEX-K02 (6.25-100 μM) is safe for wheat; it exerts no adverse effects on seed germination or seedling growth at concentrations up to 100 μM, and exhibits a weak growth-promoting effect on roots and shoots^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3106140-37-5
Peso molecular 542.54
Fòrmula C₂₈H₂₂F₄N₂O₃S
SMILES

O=C(C1=CSC(C2=CC(F)=C(C=C2)F)=N1)N[C@@H](C)C(O[C@@H](C)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kong W, et al. Scaffold Hopping of Florylpicoxamid for Structurally and Biologically Distinct Antifungal Leads. Journal of agricultural and food chemistry. 2026 Aug 12;74(31):24149-24160.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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