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Referencia número: HY-18330

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MI 63

MI 63 is an activator for p53, by targeting the MDM2 (K_i is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC₅₀ is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS.

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No. CAS: 908027-21-4
Fòrmula: C₂₉H₃₅Cl₂FN₄O₃
Peso molecular:577.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MI 63 Chemical Structure

No. CAS: 908027-21-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	1.19 μM Compound: 2a, MI-63	Growth inhibition of human A2780 cells expressing MDM2 by SRB assay Growth inhibition of human A2780 cells expressing MDM2 by SRB assay	[PMID: 21875801]
HCT-116	GI₅₀	1.3 μM Compound: 2a, MI-63	Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay	[PMID: 21875801]
HCT-116	GI₅₀	11.8 μM Compound: 2a, MI-63	Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay	[PMID: 21875801]
HCT-116	IC₅₀	0.7 μM Compound: 1, MI-63	Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]
HCT-116	IC₅₀	14.4 μM Compound: 1, MI-63	Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
LNCaP	IC₅₀	280 nM Compound: 8, MI-63	Antiproliferative activity against human LnCAP cell line with wild type p53 Antiproliferative activity against human LnCAP cell line with wild type p53	[PMID: 16759082]
PC-3	IC₅₀	18 μM Compound: 8, MI-63	Antiproliferative activity against human PC3 cell line with deleted p53 Antiproliferative activity against human PC3 cell line with deleted p53	[PMID: 16759082]
SAOS-2	IC₅₀	14.1 μM Compound: 1, MI-63	Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
SJSA-1	GI₅₀	0.55 μM Compound: 2a, MI-63	Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay	[PMID: 21875801]
SJSA-1	IC₅₀	0.5 μM Compound: 1, MI-63	Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]

Chemical Information

No. CAS 908027-21-4
Peso molecular 577.52
Fòrmula C₂₉H₃₅Cl₂FN₄O₃
SMILES

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Canner JA, et al., MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. Br J Cancer. 2009 Sep 1;101(5):774-81. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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