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Referencia número: HY-158721

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Penicinoline

(Synonyms: Marinamide)

Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells.

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No. CAS: 1214268-60-6
Fòrmula: C₁₄H₁₀N₂O₃
Peso molecular:254.24

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Penicinoline Chemical Structure

No. CAS: 1214268-60-6

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- Cellular Effect
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Bioz

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Descripciòn

Ver todos los productos específicos de isoformas Endogenous Metabolite :

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Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 20452770]
HEp-2	IC₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 20452770]
HepG2	IC₅₀	6.5 μg/mL Compound: 1	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 20452770]
HepG2	IC₅₀	7 nM Compound: 68a	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30660827]
KB	IC₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 20452770]

Chemical Information

No. CAS 1214268-60-6
Peso molecular 254.24
Fòrmula C₁₄H₁₀N₂O₃
SMILES

O=C(C1=C(C2=CC=CN2)NC3=C(C=CC=C3)C1=O)O
Synonyms

Marinamide
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Penicillium sp.
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shao CL, et al. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3284-6. [Content Brief]

[2]. Naveen B, et al. Total synthesis of penicinoline E, marinamide, methyl marinamide and their antimalarial activity[J]. ChemistrySelect, 2017, 2(11): 3256-3261.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Penicinoline

Ver todos los productos específicos de isoformas Endogenous Metabolite

Ver todos los productos específicos de isoformas Parasite

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

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Penicinoline Related Classifications

HY-158721 Related Classifications