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Referencia número: HY-163148

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PHD-IN-3

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease.

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No. CAS: 2924181-77-9
Fòrmula: C₂₀H₁₈N₆O₃
Peso molecular:390.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PHD-IN-3 Chemical Structure

No. CAS: 2924181-77-9

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
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Calculators
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Actividad biológica

Descripciòn

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease^[1].

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	EC₅₀	5 μM Compound: 15	Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis	[PMID: 38189253]
Hep 3B2	EC₅₀	6.8 μM Compound: 15	Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA	[PMID: 38189253]
Hep 3B2	EC₅₀	9 μM Compound: 15	Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis	[PMID: 38189253]
Hep 3B2	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human Hep3B cells by CellTiter-Glo assay Cytotoxicity against human Hep3B cells by CellTiter-Glo assay	[PMID: 38189253]

Chemical Information

No. CAS 2924181-77-9
Peso molecular 390.40
Fòrmula C₂₀H₁₈N₆O₃
SMILES

O[C@@H]1CCN(C1)C2=NC3=C(C(O)=C(N=C3)C(NCC4=CN=C(C=C4)C#N)=O)C=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 8. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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Chemical Information
Pureza y Documentación
Referencias

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PHD-IN-3

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PHD-IN-3 Related Classifications

HY-163148 Related Classifications