PP-60
PP-60 is an apoptosis inducer. PP-60 inhibits the proliferation of cancer cells and induces cancer cell apoptosis. PP-60 exerts anti-tumor effects in nude mouse liver tumor models. PP-60 is applicable to research related to cancers such as liver cancer, lung cancer, and prostate cancer.
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- Fòrmula: C142H252N36O40
- Peso molecular:3103.74
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
PP-60 (24 h) exhibits potent antiproliferative activity against HepG2, A549 and PC-3 cells, with IC50 values of 1.73, 2.15 and 2.69 μM[1].
PP-60 (2 μM; 2-4 h) exhibits excellent cellular uptake capacity[1].
PP-60 (0-5 μM) inhibits G2 phase cell cycle progression in HepG2 cells in a dose-dependent manner, and the percentage of cells in the G2 phase reaches approximately 35% at a concentration of 5 μM[1].
PP-60 (0-5 μM, 6 h) induces apoptosis in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:2 μM
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Incubation Time:2, 4 h
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Result:Increased FITC fluorescence signal intensity indicates a stronger cellular uptake capacity.
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Cell Line:HepG2 cells
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Concentration:0, 1, 2, 5 μM
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Incubation Time:6 h
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Result:Induced apoptosis, at a concentration of 5 μM, the apoptosis rate is approximately 80%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice (female; HepG2 (2 × 106 cells/mouse) xenograft model)[1]
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Dosage:0.5 mg per mouse
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Administration:intratumoral injection; on day 1, 6, and 15
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Result:Exhibited potent antitumor activity.
Reduced tumor volume; decreased tumor weight; showed the highest caspase 3 positive staining; reduced Ki67 positive cells to the lowest level; induced significant tumor cell apoptosis.
Chemical Information
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Peso molecular 3103.74
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Fòrmula C142H252N36O40
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Sequence
Ac-{Arg(β-Glu(1→4)-α-Glu)}-Leu-{(S)-2-(4-pentenyl)alanine}-Lys-Asp-Lys-{(S)-2-(4-pentenyl)alanine}-Lys-Gly-Ile-Gly-Lys-Leu-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-{(S)-2-(4-pentenyl)alanine}--Lys-Thr-Leu-{(S)-2-(4-pentenyl)alanine}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
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Sequence Shortening
Ac-{Arg(β-Glu(1→4)-α-Glu)}-L-{S5}-KDK-{S5}-KGIGKLAGKAALGA-{S5}-KTL-{S5}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PP-60 Related Classifications
HY-P11624 Related Classifications
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