country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-189107

Copy Link Print Information

Regrelor

Name: Regrelor
Brand: MedChemExpress
SKU: HY-189107
Availability: PreOrder

(Synonyms: INS50589 free acid)

Regrelor (INS50589 (free acid)) is a selective, reversible, and competitive P2Y12 receptor antagonist and an adenosine 5′-monophosphate derivative. Regrelor inhibits ADP (HY-W010918)-induced aggregation of human washed platelets with an IC₅₀ of 0.016 μM. Intravenous infusion of Regrelor rapidly and dose-dependently inhibits ADP-induced platelet function, and platelet function gradually recovers after cessation of infusion. Regrelor can be used for research on P2Y12-mediated platelet function and cardiovascular regulation.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 787548-03-2
Fòrmula: C₂₂H₂₅N₆O₈P
Peso molecular:532.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Regrelor Chemical Structure

No. CAS: 787548-03-2

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[2]

P2Y12 Receptor

Ver todos los productos específicos de isoformas P2Y Receptor :

In Vitro

Cardiovascular RegulationOthers

Cardiovascular Regulation

Regrelor (INS50589 (free acid)) (compound 62) inhibits ADP-induced aggregation of human washed platelets with an IC₅₀ of 0.016 μM^[1].
Regrelor inhibits platelet aggregation in human whole blood with a potency of 0.180 μM^[1].
Regrelor inhibits platelet aggregation in human platelet-rich plasma (PRP) with a potency of 0.760 μM^[1].

Others

Regrelor shows no response at the highest tested concentration in P2Y1, P2Y2, P2Y4, and P2Y6 functional assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

How to Select the Route of Administration for Mammals

Chemical Information

No. CAS 787548-03-2
Peso molecular 532.44
Fòrmula C₂₂H₂₅N₆O₈P
SMILES

OP(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(NC(NCC)=O)=NC=N3)[C@H]4[C@@H]1O[C@H](/C=C/C5=CC=CC=C5)O4)(O)=O
Synonyms

INS50589 free acid
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Douglass JG, et al. Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. Journal of medicinal chemistry. 2008 Feb 28;51(4):1007-25. [Content Brief]

[2]. Johnson FL, et al. Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589. Platelets. 2007 Aug;18(5):346-56.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Regrelor

Ver todos los productos específicos de isoformas P2Y Receptor

Actividad biológica

Descripciòn

IC50 & Target

In Vitro

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Regrelor Related Classifications

HY-189107 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target